Medical-grade Peptide Raw Material PT141

PT141 (Bremelanotide acetate) is a cyclic heptapeptide synthetic polypeptide derived from α-melanocyte-stimulating hormone (α-MSH). It is a potent agonist of melanocortin receptors (MC1R/MC4R), with its core function being the regulation of libido and sexual arousal in the central nervous system. It is the only globally approved polypeptide raw material for the treatment of central sexual dysfunction.

Amino Acid Sequence (Cyclic Heptapeptide)

Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH (Cyclization: Asp-Lys) (Lactam Bridge)

(Single Letter: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH)

Key Structural Advantages

• Cyclic Conformation: Lactam bridged ring-locked structure, extremely stable, resistant to enzymatic degradation, and long half-life
• N-Terminal Acetylation: Enhances lipid solubility and ability to cross the blood-brain barrier
• D-Phe: Enhances receptor affinity and prevents rapid degradation

• Solubility: Slightly soluble in water (with ultrasonic dissolution aid), readily soluble in DMSO and methanol
• Stability
• Lyophilized Powder: Stable for 2 years at -20℃, protected from light and sealed
• After Reconstitution: Refrigerate at 2-8℃, use within 30 days
• Storage Conditions: Dry, low temperature, protected from light, sealed, avoid repeated freeze-thaw cycles
• Density: 1.43 g/cm³
• Refractive Index: 1.679
• pKa: 3.37±0.70

Central Targeting, Unique Action

Directly acts on the hypothalamus's MC4R, promoting the release of dopamine, norepinephrine, and oxytocin, stimulating libido and sexual arousal from the central nervous system, unlike traditional peripheral vasodilators.

Dual-Effect Applicable, Suitable for Both Men and Women

Women: FDA approved for hyposexuality in premenopausal women (HSDD)

Men: Improves erectile function, still effective for those unresponsive to sildenafil.

High Stability, High Bioavailability

Cyclic structure resists enzymatic degradation, half-life approximately 2-3 hours, rapidly absorbed after subcutaneous injection.

Wide Safety Window, Controllable Side Effects

Mainly mild nausea, headache, and slight redness at the injection site; no cardiovascular risk, no drug dependence.

• Sexual Dysfunction Research: Female HSDD, Male Erectile Dysfunction (ED)
• Neuropharmacological Research: Melanocortin Receptor Pathway, Central Sexual Desire Regulation Mechanism
• Drug Development: Raw material for marketed new drugs (Vyleesi™), indication expansion research
• Other Research: Obesity Regulation (MC4R), Skin Pigmentation Regulation, Anti-inflammatory Research

For research/pharmaceutical production use only. Not for consumption or self-injection.
Handling requires professional personnel, a suitable laboratory environment, and protective equipment.
FDA approved (Vyleesi), a prescription drug raw material.
WADA List of prohibited substances, strictly forbidden for use by athletes 

Summary: PT141 (Bremerlongdan) is a high-purity, highly stable, and highly active centrally acting sexual function regulating polypeptide raw material. Prepared through solid-phase chemical synthesis, its cyclic heptapeptide structure endows it with strong stability, high receptor affinity, and the ability to cross the blood-brain barrier. Its core advantages are central targeting, dual efficacy in both men and women, and controllable safety. It is a core research and pharmaceutical raw material in the fields of sexual dysfunction, neuropharmacology, and new drug development.

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