BPC157 Raw Material Product Introduction
BPC157 (Body Protective Compound-157) is a stable synthetic 15-fifteen-peptide derived from a protective protein in human gastric juice. Its core activities include full-spectrum tissue repair, gastrointestinal protection, and anti-inflammatory regeneration, making it a star peptide raw material in regenerative medicine and sports research.
Basic Raw Material Information
| Chinese Name | Body Protective Polypeptide 157 / Gastric Derivative Fifteen-Peptide |
| English Name | BPC-157 / Bepecin |
| CAS Number | 137525-51-0 |
| Molecular Weight | 1419.54 Da |
| Appearance | White to off-white lyophilized powder |
| Purity Standard | ≥98.0% (HPLC), single impurities ≤1.0% |
| Raw Material Source | Solid-phase polypeptide synthesis (SPPS), fully chemical synthesis |
Molecular Structure and Core Characteristics
Amino Acid Sequence (15-peptide): Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
(Single Letters: GEPPPGKPADDAGLV)
Structural Advantages:
- High Acid Stability: Natural gastric-derived fragment, resistant to gastric acid and enzymatic hydrolysis, orally acceptable. Injection
- Unmodified: Linear linear peptide, simple structure, stable activity, and easy to synthesize
- Strong water solubility: Abundant polar groups, easily soluble in water and physiological saline
Physicochemical Properties (Raw Material Grade)
- Solubility: Easily soluble in water (≥10mg/mL), physiological saline, and DMSO
- Stability
- Lyophilized powder: Stable for 2 years at -20℃, protected from light and sealed
- After reconstitution: Refrigerate at 2-8℃ and use within 30 days
- Storage conditions: Dry, low temperature, protected from light, and protected by inert gas
- Density: 1.366 g/cm³
- Boiling point: 1802.9℃ (760mmHg)
- pKa: 3.36
Core Advantages of the Raw Material
Full-spectrum repair activity
Covering gastrointestinal tract, muscle, tendon, ligament, bone, nerve, and skin, promoting synergistic regeneration of multiple tissues
Dual routes of administration
Oral / Effective by injection, high bioavailability, suitable for various research scenarios. Extremely wide safety window. No lethal doses observed in animal studies, no significant toxicity, and minimal side effects (slight redness at the injection site, transient nausea). Clear mechanism. Activates the FAK-Paxillin pathway, promotes VEGF angiogenesis, reduces TNF-α/IL-6 inflammation, and increases collagen synthesis. V. Main uses of raw materials (research/ (Industrial)
- Gastrointestinal Protection Research: Gastric ulcers, enteritis, intestinal fistulas, liver damage, mucosal repair
- Sports Injury Repair: Tendinitis, ligament sprains, muscle tears, fracture healing, joint anti-inflammatory
- Neuroprotection: Spinal cord injury, cerebral ischemia, Parkinson's disease, depression (brain-gut axis regulation)
- Regenerative Medicine: Skin wounds, vascular repair, organ protection, anti-aging
- Drug Development: Candidate peptide raw materials for gastrointestinal diseases, orthopedics, and neurology
Quality Specifications (Standard Raw Material)
| Appearance | White to off-white lyophilized powder |
| Purity (HPLC) | ≥98.0% |
| Impurities | ≤1.0% |
| Moisture | ≤10.0% |
| Acetate | 5.0%–12.0% |
| Endotoxin | <1 EU/mg (injection grade) |
| Packaging | 1mg/5mg/10mg/1g lyophilized powder vial |
Safety and Compliance Notes
Research Use Only / For industrial use only, not for medical, food, or human injection. Operation requires professional personnel, a suitable laboratory environment, and protective equipment. Not approved for FDA/EMA clinical trials; strictly prohibited for human medical use.
In summary, BPC157 is a high-purity, highly stable, and highly safe gastric repair peptide raw material, prepared through solid-phase chemical synthesis. Its structure is a 15-amino acid linear peptide, possessing four core advantages: full-spectrum tissue repair, gastrointestinal protection, anti-inflammatory regeneration, and dual-route drug delivery. It is a top-tier research raw material in the fields of gastrointestinal diseases, sports injuries, neuroprotection, and regenerative medicine.
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