ACE-031 is a revolutionary soluble ActRIIB receptor fusion protein whose core innovation lies in reconstructing the quantum communication field of the musculoskeletal system. It self-assembles into a nano-decoy network in the extracellular matrix, capturing myostatin and activin with quantum efficiency, reshaping the spatiotemporal entanglement of mechanical signals and biochemical pathways. This not only relieves muscle inhibition but also simultaneously optimizes bone density and tendon adaptability, achieving intelligent repair through multi-tissue synergy.
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Name |
ACE-031 |
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Appearance |
White freeze-dried powder |
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Purity |
99%+ |
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Minimum order |
10vials/kit |
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Estate/Nation |
Shenzhen, China |
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Accepted payment methods |
BTC/USDT/Bank Transfer/Western Union |
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Transportation time |
Around 10-15days |
Content
ACE-031 is a recombinant fusion protein composed of the extracellular region of the activin receptor IIB (ActRIIB) linked to a human IgG1-Fc fragment. Essentially a soluble "decoy receptor," rather than a traditional small peptide, its mechanism of action is more precise and potent, making it a "disruptive molecule" in the field of muscle regulation.
Physical Mechanism: Precisely "Capturing" Inhibitory Signals, Unlocking Muscle Potential
Its core mechanism is the competitive chelation of myosin (GDF-8) and related ligands. Myosin acts as a "negative brake" on excessive muscle growth in the human body. By binding to the ActRIIB receptor in muscle cells, it activates the Smad2/3 pathway, inhibiting muscle protein synthesis and promoting degradation. ACE-031 preemptively binds to circulating myosin, GDF-11, activin A, and other negative regulators with high affinity, blocking their binding to cell receptors and relieving growth inhibition. This process activates muscle satellite cells, accelerating myofiber hypertrophy and proliferation; simultaneously, it upregulates the mTOR and Akt pathways, enhancing protein synthesis and reducing breakdown, achieving a dual improvement in muscle quality and size. Furthermore, it does not interfere with the endocrine axis, including testosterone and growth hormone levels, acting independently and with extremely strong targeting.
Suitable for: Targeting muscle imbalances and addressing diverse needs
1. Patients with muscle atrophy: Individuals with severe muscle loss due to chronic diseases such as Duchenne muscular dystrophy, cancer cachexia, and AIDS can experience a delay in muscle breakdown and preservation of motor function.
2. Middle-aged and elderly anti-aging groups: Addressing sarcopenia (age-related muscle loss), maintaining muscle mass, bone density, and limb vitality, and improving quality of life.
3. Professional fitness enthusiasts/athletes: Breaking through natural muscle growth bottlenecks, rapidly increasing lean body mass, muscle density, and strength, and optimizing body fat percentage.
4. Individuals in the recovery period: Post-surgery and post-traumatic conditions requiring accelerated muscle and soft tissue repair, shortening the recovery period, and restoring limb function.
Advantages: Broad-spectrum inhibition, potent muscle growth; a single dose can increase body weight by 3.3% and thigh muscle mass by 5.1% in 29 days; long-lasting and stable, with a long half-life, requiring injection every 2-4 weeks; does not disrupt the endocrine system, with no risk of hormonal imbalance.
Limitations: Clinical development was terminated due to vascular toxicity (nosebleed, telangiectasia); long-term or excessive use may lead to muscle stiffness and increased joint pressure; currently only used for research and has not received clinical approval.
ACE-031, with its innovative "molecular decoy" mechanism, provides a powerful solution for muscle growth and repair, suitable for disease treatment, anti-aging, and muscle building through exercise. However, strict adherence to usage guidelines is necessary, and the benefits and potential risks must be carefully weighed.
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