TB500 (Thymosin β4 Fragment) Raw Material Product Introduction
TB500 is a synthetic heptapeptide derived from the core active site of natural thymosin β4 (Tβ4). Its core activities include systemic tissue repair, strong anti-inflammatory properties, and promotion of angiogenesis. It is a top-tier peptide raw material for sports injuries, regenerative medicine, and wound healing.
Basic Raw Material Information
| Chinese Name | Thymosin Beta-4 Acetate Fragment / TB500 |
| English Name | TB-500 / Thymosin Beta-4 Fragment |
| CAS Number | 885340-08-9 |
| Molecular Weight | 889.01 Da |
| Appearance | White to off-white lyophilized powder |
| Purity Standard | ≥98.0% (HPLC), single impurities ≤1.0% |
| Source of Raw Material | Solid-phase peptide synthesis (SPPS), fully chemical synthesis |
Molecular Structure and Core Features
Amino Acid Sequence (N-acetylated heptapeptide)
Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln
(Single Letters: Ac-LKKTETQ)
Key Structural Advantages
- Simplified Activity: Truncation of the actin-binding core region at positions 17-23 of Tβ4, retaining... 100% Repair Activity
- N-Terminal Acetylation: Resistant to enzymatic degradation, long half-life, high stability, superior to natural Tβ4
- Small Molecule Penetration: Small molecular weight, strong tissue penetration, rapid systemic distribution
Physicochemical Properties (Raw Material Grade)
- Solubility: 250 mg/mL (water, ultrasonically assisted dissolution), readily soluble in DMSO and methanol
- Stability
- Lyophilized powder: Stable for 2 years at -20℃, protected from light and sealed
- After reconstitution: Refrigerate at 2-8℃, use within 30 days
- Storage Conditions: Dry, low temperature, protected from light, inert gas protection
- Density: 1.281 g/cm³
- Boiling Point: 1405.0℃ (760 mmHg)
- pKa: 3.20±0.10
Core Advantages of Raw Material
Systemic Repair, Precise Targeting
Binding with G-actin, it regulates the cytoskeleton, promotes cell migration, angiogenesis, and collagen deposition, covering all tissues including muscles, tendons, ligaments, skin, nerves, and myocardium.
Strong anti-inflammatory, minimal scarring
- Significantly downregulates TNF-α and IL-6, inhibits fibrosis, accelerates healing, and reduces scarring.
- Small molecule, highly penetrating, long-lasting
- Rapidly penetrates tissues, has a long half-life, and acts systemically, requiring no local injection.
- Extremely wide safety window
- Animal studies showed no significant toxicity, no mutagenicity, no teratogenicity, and minimal side effects (slight redness at the injection site, transient fatigue).
Main Uses of Raw Material (Research/Pharmaceutical)
- Sports Injury Repair: Tendinitis, ligament tears, muscle strains, articular cartilage damage
- Wound Healing: Surgical incisions, burns, diabetic foot ulcers, chronic wounds
- Anti-inflammatory and Anti-fibrotic: Arthritis, pneumonia, liver fibrosis, kidney damage
- Neurological/Cardiovascular Protection: Spinal cord injury, cerebral ischemia, post-myocardial infarction repair
- Regenerative Medicine: Stem cell activation, tissue engineering, anti-aging research
Quality Specifications (Standard Raw Material)
| Appearance | White to off-white lyophilized powder |
| Purity (HPLC) | ≥98.0% |
| Impurities | ≤1.0% |
| Moisture | ≤8.0% |
| Acetate | 5.0%–12.0% |
| Endotoxin | <1 EU/mg (injection grade) |
| Packaging | 1mg/5mg/10mg/1g lyophilized powder vial |
Safety and Compliance Notes
For research/industrial use only. Not for medical, food, or self-injection.
Operation requires professional personnel, a suitable laboratory environment, and protective equipment.
WADA This substance is banned by the World Anti-Doping Agency and is strictly prohibited for use by athletes. It has not received FDA/EMA clinical approval and is strictly prohibited for human medical use.
In summary, TB500 is a high-purity, highly stable, and highly active heptapeptide raw material for the synthesis of thymosin β4. Its Ac-LKKTETQ structure endows it with four core advantages: small molecule penetration, systemic repair, strong anti-inflammatory properties, and long-lasting stability. It is a core research raw material in the fields of sports injuries, wound healing, anti-inflammatory and anti-fibrotic effects, and neuro/cardiovascular protection.
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