Application Areas
Sexual Neuroendocrine Research: As a high-affinity probe for MC4R/MC3R, it can be used to study the hypothalamic-limbic system's motivational neural circuits, dopaminergic reward mechanisms, and oxytocin pathway regulation.
Male Erectile Dysfunction (ED) Mechanism Research: It induces penile erection through central autonomic pathways, suitable for exploring non-vascular-dependent erection mechanisms and synergistic effects with PDE5 inhibitors.
Female Hyposexuality Disorder (HSDD) Research: The FDA has approved Bremelanotide for HSDD in premenopausal women, providing a clinical translation reference for research on the central mechanisms of female sexual arousal disorders.
Energy Metabolism and Appetite Regulation: MC4R is a core regulatory node for energy balance; PT-141 can be used to study the neuroregulatory mechanisms of obesity, metabolic syndrome, and appetite.
Melanocortin Systems Pharmacology: As a non-selective MCR agonist, it can be used to compare the functional differences of different melanocortin receptor subtypes and for selective ligand development research.
Storage and Usage
PT-141 While the cyclic structure provides good protease stability, its peptide chains are still sensitive to temperature, humidity, and oxidation. Therefore, the following operating procedures must be strictly followed:
1. Storage of Lyophilized Powder
Temperature: Unreconstituted lyophilized powder should be stored at -20°C or below in a dry, light-protected environment. For long-term storage, an ultra-low temperature environment of -80°C is recommended to maximize stability.
Conditions: Keep sealed and dry to prevent moisture intrusion. The lyophilized powder state is the most stable physical form of the peptide; the absence of water molecules significantly reduces hydrolytic degradation pathways.
Contraindications: Repeated freeze-thaw cycles are strictly prohibited. Aliquoting is recommended.
2. Reconstitution Procedure
Solvent: Use sterile, antimicrobial water (containing 0.9% benzyl alcohol) for reconstitution, which can effectively inhibit microbial contamination and prolong solution stability.
Procedure: Before reconstitution, disinfect the stopper with an alcohol swab, slowly pour in the solvent, and gently swirl to aid dissolution. Avoid vigorous shaking to prevent air bubbles or shear force damage to the peptide chain structure.
Concentration Reference: 10 mg of lyophilized powder can be reconstituted with 2 mL of antibacterial water to obtain a 5 mg/mL (5000 mcg/mL) solution.
3. Storage after Reconstitution
Temperature: The reconstituted solution should be refrigerated at 2–8°C and stored away from light.
Shelf Life: It is recommended to use within 14–30 days. Increased molecular mobility in solution significantly increases the risk of hydrolysis, deamidation, and oxidation.
Allowing Strategy: For long-term storage of the reconstituted solution, single-use aliquoting is recommended. After aliquoting, store at -20°C to avoid mechanical damage and aggregation caused by repeated freeze-thaw cycles.
Contraindications: If the solution becomes turbid, precipitates, or shows visible particles, it should be discarded immediately.
4. Administration Method (Research Reference)
Route: Subcutaneous injection, alternating between abdominal and thigh injection sites.
Needles: 27–31G insulin needles are recommended.
Note: The dosing regimen needs to be determined based on the specific study design; reconstitution and administration should be performed under aseptic conditions in a clean environment (such as a laminar flow hood) to minimize the risk of microbial contamination.
Why Choose Us?
As the original manufacturer of PT-141, we possess the following core advantages:
1. Direct Supply, Controllable Costs
We have independent production capabilities, controlling the entire supply chain from raw materials to finished products. Compared to trading companies or agents, we can provide customers with a more competitive pricing system while ensuring a stable and continuous supply, eliminating the risk of supply disruptions at intermediate stages.
2. Professional Production Equipment and Processes
The company is equipped with standardized production workshops and advanced peptide synthesis equipment, possessing precise and efficient analytical instruments (HPLC, LC-MS, GC-MS, NMR, etc.), and has established a scientific and rigorous quality management system. Each batch of products undergoes strict quality inspection to ensure that key indicators such as peptide purity, impurity control, and content meet high standards.
3. Purity and Quality Assurance
We strictly implement end-to-end quality control from raw material warehousing to finished product delivery. Product purity reaches over 98%, and customized purity specifications can be provided according to customer needs. Each batch of products is accompanied by a complete Certificate of Account (COA), ensuring traceability of quality.
4. Stable Supply and Ample Production Capacity
Leveraging our large-scale production capacity and mature supply chain management system, we can meet various order needs, from small-batch research trials to large-scale industrial purchases. Flexible packaging specifications are available, offering different packaging options such as 1g, 100g, 1kg, and even 25kg according to customer requirements.
5. After-Sales Guarantee and Technical Support
We have a technical team composed of experienced R&D personnel with professional capabilities in the synthesis, purification, analysis, and application of peptide compounds. Whether it's pre-sales consultation, usage guidance, or after-sales issues, we provide professional and timely technical support and service guarantees.
FAQ
Q: Where are your products manufactured?
A: Our products are from Shenzhen, China.
Q: What is the minimum order quantity? A: Minimum order quantity is 10 bottles/set.
Q: How long does it take to ship?
A: In-stock orders will be shipped within 24 hours.
Q: What purity level can you provide?
A: Standard purity 99%.
Q: Which courier service do you use?
A: FedEx, DHL, UPS, and postal services are available.
Q: How long does shipping take?
A: Approximately 10-15 days.
Q: Can you provide a COA (Certificate of Analysis) report and HPLC (High-Performance Computing) report?
A: Yes, all goods undergo professional testing before shipment.
Q: Do you support OEM/ODM?
A: OEM/ODM service is supported, subject to minimum order quantity requirements.
Q: What are your after-sales service details?
A: After the customer receives the goods, if the quality problem is confirmed to be caused by our production, they can enjoy free replacement or refund. We adhere to a pragmatic and responsible service principle, actively responding to and properly handling all kinds of issues, without shirking responsibility or avoiding problems, and fully protecting customer rights.
Q: What payment methods are available?
A: We support bank transfers, Bitcoin, Transferwise, and Xoom.
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