This is Pinealon (a pineal tripeptide biomodulator, Glu-Asp-Arg / EDR), a pineal gland-targeting short peptide developed by the Khavinson school of thought. It's related to Vilon, which was mentioned earlier-Vilon controls immunity, while Pinealon specifically targets the brain and pineal gland. Research suggests it can penetrate neuronal nuclear membranes, interact with DNA promoter regions, downregulate oxidative stress, and help the pineal gland restore age-related melatonin rhythms. It's often used to improve brain fog, alleviate sleep lag, or protect cognition.
Core Functions:
Powerful removal of reactive oxygen species (ROS) in the brain, inhibition of ERK1/2 damage pathways, reduction of spontaneous neuronal apoptosis, and protection of hypoxic and ischemic brain cells, suitable for repair experiments in models of cerebral infarction and traumatic brain injury.
Regulation of melatonin-related pathways, adjustment of disordered circadian rhythms, improvement of age-related sleep difficulties and shallow sleep, and stabilization of pineal gland secretion function.
Upregulation of serotonin secretion in the brain, improvement of memory and spatial learning ability in elderly models, and alleviation of cognitive decline caused by neurodegenerative diseases.
Epigenetic regulation, combined with nerve cell DNA, activates antioxidant and synaptic repair genes, maintains dendritic spine integrity, and delays brain tissue aging and atrophy.
It reduces fetal neurological damage caused by high homocysteine levels during pregnancy and has stable experimental results in developmental neurotoxicity studies.
Core Advantages:
Specifically targets the brain and pineal gland, complementing Epitalon, which focuses on telomere activation. A single formulation can simultaneously assess both neurological repair and systemic anti-aging indicators, eliminating the need to purchase two separate raw materials.
The tripeptide has an extremely low molecular weight, easily penetrating the blood-brain barrier and nuclear membrane. It is effective at low nanomolar concentrations, requiring less consumables and resulting in cost-effective experiments.
It gently regulates apoptosis in both directions, without excessively inhibiting or inducing cell death. Long-term administration to animals shows almost no stress or toxicity reactions, and experimental data exhibits excellent reproducibility.
Sufficient literature support exists, with mature dosage references available for various models of cerebral ischemia, Alzheimer's disease, sleep disorders, and prenatal neurological injury, providing strong support for research papers.
It exhibits good physicochemical compatibility, dissolving stably in neutral culture media and injection buffers, making it suitable for both in vitro cell culture and in vivo animal administration.
Storage & Reconstitution
Unreconstituted (lyophilized powder): Seal the original bottle and store at -20°C for 12–24 months; for short-term storage (1–3 months), refrigerate at 2–8°C, protected from light. Prevent moisture and repeated freeze-thaw cycles.
Reconstitution: Slowly pour sterile antibacterial water (BAC water) along the bottle wall, gently rotating/rolling the bottle-do not shake vigorously (even though the tripeptide is small, foaming still affects its effectiveness). Usually, add 1–2 mL of BAC water.
After reconstitution: Refrigerate at 2–8°C, protected from light, and use within 14–28 days (as indicated on the bottle). Discard immediately if it becomes cloudy/contains particles/changes color. Do not refrozen after reconstitution.
⚠️ Special Notes
**Use with caution in cases of epilepsy/severe neuropsychiatric disorders:** Due to its action on the CNS, use with caution in individuals with a history of epilepsy, or during active phases of severe depression/bipolar disorder (theoretical risk, limited data).
**Allergy:** Contraindicated in individuals with known hypersensitivity to peptides or excipients; discontinue use immediately and seek medical attention if rash, urticaria, or difficulty breathing occurs.
**Injection reaction:** Local redness, pain, and induration are common; alternating injection sites (abdomen → thigh → upper arm) may alleviate these symptoms.
**Not recommended for pregnant women, breastfeeding mothers, or individuals under 18 years of age (insufficient safety data).
**Initial use:** Some individuals may report more vivid dreams/mild morning drowsiness, which usually disappears after adaptation; if insomnia worsens, the injection may be switched to the morning instead of the evening.
**Discontinue use in cases of active brain infection or skin infection at the injection site.**
**How to order?**
First, please inform us of your needs or application scenario.
Second, we will provide a quotation based on your needs or our suggestions.
Third, the customer confirms the sample and pays a deposit.
Fourth, we will arrange production. Bulk orders enjoy discounts.
How is the quality of your products? First of all, our products are of excellent and consistent quality. We conduct 100% testing before shipment.
Therefore, we implement strict quality control before shipment. If any quality problems are found to be caused by us, we will replace the product free of charge or provide a refund.
How to establish a long-term, positive partnership with us?
1. We insist on providing high-quality products and competitive prices to ensure customer benefits;
2. We respect every customer, treat them as friends, and sincerely do business and make friends with them, no matter where they come from.
Hot Tags: purchase high-purity lyophilized powder pinealon 5mg/vial, China purchase high-purity lyophilized powder pinealon 5mg/vial manufacturers, suppliers, factory
