Applicable Methods (Clinical Protocol / Research-Level Guidelines)
Route: Subcutaneous injection only (SC); alternating between abdomen (periumbilical ≥2 cm), lateral thigh, and dorsal upper arm; IV/IM is contraindicated.
Frequency: Once a week, on the same day of the week, unaffected by food intake.
Dosage titration (4-week increments for Phase III, 2-week increments for Phase II)
Starting dose: 0.6 mg/week (0.3 mg in some regimens)
Increase every 4 weeks: 0.6 → 1.2 → 2.4 → 3.6 → Maintenance dose 3.6 or 4.8–6.0 mg/week
Target maintenance dose: Obesity 4.8–6.0 mg; MASH 2.4–4.8 mg; T2DM 0.3–2.7 mg (depending on the regimen)
Reconstitution in study vials (using 10 mg lyophilized powder as an example)
Solvent: Sterile antimicrobial water (BAC water) slowly poured along the vial wall, gently swirled to mix, do not vortex
Volume: Add 2 mL → 5 mg/mL (1 unit U-100 = 50) µg)
Aspiration: Convert units according to the titration table, rotate injection sites.
Common adverse reactions: Dose-dependent gastrointestinal reactions (nausea ~66%, diarrhea ~49%, vomiting ~41%), mostly occurring in the first 6 weeks of titration; slow titration can reduce the discontinuation rate.
Contraindications: For registration clinical trials or RUO studies only; self-injection/consumption is strictly prohibited.
Application Scenarios
Long-term weight management in obese/overweight adults (BMI ≥27 kg/m², with or without T2DM; SYNCHRONIZE-1/2)
MASH (metabolic steatohepatitis, formerly NASH) with fibrosis F2–F3 (LIVERAGE), compensated cirrhosis F4 (LIVERAGE-Cirrhosis); stage II, highest improvement rate at 48 weeks liver biopsy ~63.8% vs placebo 15.2%
Type 2 diabetes co-management of blood glucose and weight (HbA1c reduction can reach...) ~1.6%, weighted lower than the first two items)
Cardiovascular-Renal-Metabolic (CKM) Risk Population (SYNCHRONIZE-CVOT)
Storage Conditions:
Based on its chemical structure characteristics of a 29-amino acid peptide and C18 fatty acid modification, Survodutide must be stored strictly according to the following specifications: Unopened/Powder State: Should be sealed and protected from light, stored in a frozen environment at -20°C, where it can generally be stably stored for 3 years; if refrigerated at 4°C, it can be stored for 2 years.
Reconstituted/Prepared State: Once dissolved in a solvent, it must be immediately placed in a low-temperature environment at -80°C (storage for 6 months) or -20°C (storage for 1 month). Repeated freeze-thaw cycles are strictly prohibited to prevent peptide chain degradation and inactivation.
Transportation Requirements: Usually transported using ice packs or dry ice cold chain to ensure that the drug does not denature during transportation.
FAQ
Q: What is the minimum order quantity?
A: The minimum order quantity is 10 bottles/set.
Q: How long does it take to ship?
A: In-stock orders will be shipped within 24 hours.
Q: What purity level can you provide?
A: Standard purity 99%.
Q: Which courier service do you use?
A: FedEx, DHL, UPS, and postal services are available.
Q: How long does shipping take?
A: Approximately 10-15 days.
Q: Can you provide a COA (Certificate of Account) quality inspection report and HPLC (High-Performance Computing) report?
A: Yes, all goods undergo professional testing before shipment.
Q: Do you support OEM branding?
A: OEM branding is supported, subject to minimum order quantity requirements.
Q: What are your after-sales service terms?
A: After the customer receives the goods, if the quality problem is confirmed to be caused by our production, they can enjoy free replacement or refund. We adhere to a pragmatic and responsible service principle, actively responding to and properly handling all kinds of issues, without shirking responsibility or avoiding problems, and fully protecting customer rights.
Q: What payment methods are available?
A: We support bank transfer, Bitcoin, Transferwise, and Xoom.
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