Instructions for Use:
Oral administration with zero utilization (complete peptidase digestion); injection and intranasal administration are the two main routes.
Obstetric IV drip (Pharmacopoeia standard): Induction/oxygenation: 2.5–5 U dissolved in normal saline to 0.01 U/mL, initial 0.001–0.002 U/min, increasing by 0.001–0.002 U/min every 15–30 min, usually maintaining at 0.002–0.005 U/min, with an upper limit of 0.02 U/min; postpartum hemorrhage: 0.02–0.04 U/min; after placental delivery: 5–10 U/mL. An infusion pump must be used; single-step injection is contraindicated.
Intranasal administration (behavioral studies): Literature commonly uses a single 24 IU dose (3 sprays x 4 IU/spray per nostril) or 10–40 IU/day divided into 1–2 doses; for ASD children, the pilot dose is 0.4 IU/kg/dose; research-grade acetate powder can be converted to 50–200 μg SC control, but behavioral evidence is primarily intranasal. Nasal mucosa → olfactory/trigeminal bypass 10–15 minutes into CSF; peripheral blood concentration does not necessarily reflect central concentration.
Reconstitution (research-grade acetate): Lyophilized powder is gently pushed along the wall with sterile water/0.9% antibacterial water, avoiding core flushing and vortexing. Roll in the palm for 2–5 minutes to obtain a clear, colorless solution; 5 mg + 5 mL = 1 mg/mL. Mg²⁺ (1–2 mM) can stabilize OXTR in a high affinity state; some are added according to protocol.
Timing: In obstetrics, administration is monitored along with uterine contractions; behavioral studies often involve single morning dosing or consistent dosing at fixed times for 2–4 weeks; the inverted U-shaped dose-response model determines that "higher doses are not optimal."
Application Scenarios
Obstetric Essentials: Induction/labor stimulation to strengthen uterine contractions, prevention of postpartum hemorrhage in the third stage of labor, oxytocin challenge test (OCT);
Lactation Assistance: Nasal spray/drops 2–3 minutes before breastfeeding to stimulate milk production (without increasing milk yield);
Behavioral Neuroscience: Social trust, face recognition, fear extinction, partner attachment, ASD social cognition (NEJM2021 Sikich large sample negative, but subgroup and meta-analysis still support around 48 IU/day inverted U);
Stress and Eating: Prader-Willi binge eating, pre-meal intranasal administration of approximately 150 kcal (Plessow 2024), stress-induced cortisol decline;
Cardiovascular Bystander Effects: Endothelial NO release, synergistic effect of atrial natriuretic peptide, ischemic preconditioning;
Stem Cell/Regeneration: Adult myocardial stem cell differentiation, osteogenic deviation, still under investigation regarding mechanisms
Storage and Stability
Disulfide bonds are critical; reducing agents and light are mortal enemies.
Freeze-dried powder: Original aluminum foil + desiccant, -20℃ 24–36 months, 2–8℃ short-term storage ≤6 months; protect from light (amber bottle or aluminum foil), return to room temperature and cover to prevent condensation;
Reconstituted solution: 2–8℃, protected from light, upright, antibacterial water 14–30 days, sterile water 24–48 hours; do not freeze after reconstitution, freeze-thaw will oxidize and break disulfide bonds; aliquoting into single-use tubes can be stored at -20℃, but this is non-standard operation;
Deterioration criteria: should be clear and colorless; discard if pale yellow/cloudy/flocculated/sulfurized smell; a clear appearance may indicate ring-opening and inactivation; beyond the expiration date, treat as waste liquid;
Handling precautions: Do not store with DTT, β-mercaptoethanol, or TCEP (to break disulfide bonds); do not use vortex sonication; do not expose to direct UV light; use nitrile gloves for sweat-proof reduction.
FAQ
Q: What is the minimum order quantity? A: Minimum order quantity is 10 bottles/set.
Q: How long does it take to ship?
A: In-stock orders will be shipped within 24 hours.
Q: What purity level can you provide?
A: Standard purity 99%.
Q: Which courier service do you use?
A: FedEx, DHL, UPS, and postal services are available.
Q: How long does shipping take?
A: Approximately 10-15 days.
Q: Can you provide a COA (Certificate of Analysis) report and HPLC (High-Performance Computing) report?
A: Yes, all goods undergo professional testing before shipment.
Q: Do you support OEM/ODM?
A: OEM/ODM service is supported, subject to minimum order quantity requirements.
Q: What are your after-sales service details?
A: After the customer receives the goods, if the quality problem is confirmed to be caused by our production, they can enjoy free replacement or refund. We adhere to a pragmatic and responsible service principle, actively responding to and properly handling all kinds of issues, without shirking responsibility or avoiding problems, and fully protecting customer rights.
Q: What payment methods are available?
A: We support bank transfers, Bitcoin, Transferwise, and Xoom.
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