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N-Acetyl Epitalon Amidate Regulates Circadian Rhythms And Delays Aging. CAS: 307297-39-8

N-Acetyl Epitalon Amidate Regulates Circadian Rhythms And Delays Aging. CAS: 307297-39-8

N-Acetyl Epitalon Amidate (also known as Ac-Epithalon-NH₂ or Ac-AEDG-NH₂) is a chemically modified tetrapeptide. Its parent compound, Epitalon (sequence Ala-Glu-Asp-Gly), was synthesized by Russian scientist Professor Vladimir Khavinson in the early 1990s based on the active ingredient Epithalamin, an extract from bovine pineal glands.

Product Introduction

**Applicable Methods**

- **Route of Administration**: Due to its polypeptide structure being easily cleaved by digestive enzymes, its oral bioavailability is extremely low. Therefore, it is primarily administered via subcutaneous injection, usually targeting the abdominal or lateral thigh fat layer.

- **Dosage and Cycle**: Currently, there is no unified standard clinical dosage for humans. Existing protocols are mostly based on extrapolation from animal experimental data. Common research or empirical usage employs a "cyclic dosing" model, such as once-daily injection for 10 to 20 days as one cycle, followed by a break of several months.

- **Preparation Requirements**: This substance is usually in lyophilized powder form and must be reconstituted with sterile water for injection or antibacterial water before use. The reconstituted solution should be kept away from vigorous shaking to prevent peptide chain breakage.

 

 

** Application Scenarios**

- **Anti-aging and Longevity Intervention**: Core application scenario. It aims to improve overall bodily function and extend healthy lifespan by activating telomerase, repairing shortened telomeres, and delaying cellular replicative aging.

- **Circadian Rhythm Regulation**: Based on Epitalon's regulatory effect on pineal gland function, this derivative has been used to improve sleep disorders in the elderly, regulate melatonin secretion, and restore circadian rhythms.

- **Neuroprotection and Cognitive Improvement**: Some studies suggest that it may have potential preventive or ameliorative effects on neurodegenerative diseases (such as Alzheimer's disease) through antioxidant and anti-apoptotic mechanisms.

- **Skin Rejuvenation**: Utilizing its potential to promote cell regeneration and collagen synthesis, it can help improve skin elasticity and reduce wrinkles.

 

** Storage Conditions**

- **Lyophilized Powder State**: Unreconstituted lyophilized powder is highly sensitive to temperature. It is recommended to seal it tightly, protect it from light, and store it in a -20°C freezer for long-term stable storage (usually more than 2 years). Refrigeration at 4°C will shorten the shelf life accordingly.

- **Reconstituted State**: Once a solvent is added, the peptide chains are easily degraded. It must be immediately stored in a refrigerator at 2°C to 8°C, protected from light. Freezing the reconstituted solution is strictly prohibited. It is recommended to use within 2-4 weeks after reconstitution. Discontinue use if turbidity or precipitation occurs.

 

FAQ
Q: What is the minimum order quantity?

A: The minimum order quantity is 10 bottles/set.

Q: How long does it take to ship?

A: In-stock orders will be shipped within 24 hours.

Q: What purity level can you provide?

A: Standard purity 99%.

Q: Which courier service do you use?

A: FedEx, DHL, UPS, and postal services are available.

Q: How long does shipping take?

A: Approximately 10-15 days.

Q: Can you provide a COA (Certificate of Authorization) and HPLC (High-Performance Computing) report?

A: Yes, all goods undergo professional testing before shipment.

Q: Do you support OEM/ODM?

A: OEM/ODM service is supported, subject to minimum order quantity requirements.

Q: What are the after-sales service procedures? A: After the customer signs for the goods, if the quality problem is confirmed to be caused by our production, they can enjoy free replacement or refund. We adhere to the service principle of pragmatism and responsibility, actively respond to and properly handle all kinds of issues, without shirking responsibility or avoiding problems, and do our best to protect the rights and interests of our customers.

Q: What payment methods are available?

A: We support bank transfer, Bitcoin, Transferwise, and Xoom.

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