I. Product Details
Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It is a structurally optimized analog of the human endogenous immunomodulatory peptide Tuftsin. By extending the Pro-Gly-Pro fragment at the C-terminus, it significantly enhances metabolic stability and central nervous system activity, exhibiting both neural and immunomodulatory properties.
II. Product Parameters
CAS No.: 129954-34-3
Molecular Formula: C₃₃H₅₇N₁₁O₉
Molecular Weight: Approx. 751.89 Da
Appearance: White or off-white loose lyophilized powder
Purity: Research grade ≥98% / Pharmaceutical grade ≥99.5% (HPLC)
Solubility: Easily soluble in water, PBS, and physiological saline; insoluble in nonpolar organic solvents
Stability: Dry powder can be stored stably for ≥2 years at -20℃ protected from light; aqueous solution can be stored stably for 3 months at 4℃; free of easily oxidized residues, high chemical stability
III. Product Functions and Effects
Anti-anxiety and Mood Regulation: As a positive allosteric modulator of GABA-A receptors, it enhances inhibitory neurotransmission, effectively relieving anxiety, fear, and aggression, and is less likely to cause the sedation and dependence commonly found in benzodiazepines.
**Nootropic and Stress-Resistant Effects:** Regulates the metabolism of monoamine neurotransmitters such as serotonin and dopamine, improving mental clarity, learning and memory, and reducing acute stress responses.
**Neurotrophic and Protective Effects:** Rapidly upregulates the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, promoting neuronal survival and synaptic plasticity.
**Immune Regulation:** Inheriting the properties of tuftsin, it regulates T cell homeostasis and cytokine (such as IL-6) expression, enhancing macrophage phagocytic activity.
**IV. Core Advantages:**
**High Safety Homologous Structure:** The core sequence is highly homologous to natural human tuftsin, exhibiting no immunogenicity and low likelihood of inducing antibody responses.
**Excellent Stability:** C-terminal modification makes it resistant to degradation by serum peptidases, resulting in a much longer half-life than natural tuftsin, and it is also resistant to storage and oxidation inactivation.
** Multi-target synergistic effect: Simultaneously targets GABA, serotonin, dopamine, and the immune system, achieving a stable regulation that is "anti-anxiety without sluggishness and cognitive enhancement without agitation."
Dual efficacy: One bottle addresses both the research and application needs of the nervous system (anti-anxiety/cognitive enhancement) and the immune system (immune balance).
V. Origin
Selank was developed by the Institute of Molecular Genetics (IMG RAS) of the Russian Academy of Sciences. Researchers modified the natural immune tetrapeptide Tuftsin (Thr-Lys-Pro-Arg) and added a Pro-Gly-Pro tripeptide tail to resist rapid enzymatic degradation in the body. This achievement was approved by the Russian Ministry of Health in 2009 for marketing as a nasal spray (trade name Selank) for the treatment of generalized anxiety disorder and neurasthenia.
VI. Precautions
Usage Restrictions: These reagents are for laboratory research only. They are strictly prohibited for human self-experimentation or clinical injection (although nasal sprays are available in Russia, cross-border unauthorized use carries risks).
Handling Procedures: It is recommended to handle these reagents in a fume hood while wearing gloves. For reconstitution, sterile water/physiological saline is recommended; avoid vigorous shaking. After reconstitution, aliquot and store below -20°C, avoiding repeated freeze-thaw cycles.
Compatibility: Avoid prolonged coexistence with strong acids, strong alkalis, or strong oxidizing agents.
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