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IGF1-LR3 (0.1 Mg/vial, 1 Mg/vial) For Cell Culture And Biopharmaceuticals; CAS: 946870-92-4

IGF1-LR3 (0.1 Mg/vial, 1 Mg/vial) For Cell Culture And Biopharmaceuticals; CAS: 946870-92-4

IGF1-LR3 is a long-acting structural variant of insulin-like growth factor-1 (IGF-1) that continuously activates downstream signaling of the IGF-1 receptor (IGF-1R) by reducing affinity for IGF-binding proteins and extending its circulating half-life. This product is intended solely for *in vitro* experiments and mechanistic research; it is not for human use and is not intended for any therapeutic, health-related, or performance-enhancing purposes.

Product Introduction

**Key Application Scenarios**

**Scientific Research and Biopharmaceuticals:** IGF-1 LR3 is widely used in large-scale mammalian cell culture systems. As a critical additive in serum-free media, it supports the high-density growth and recombinant protein expression of engineered cell lines such as CHO and HEK293. Its stability and high specific activity make it a vital tool in upstream biopharmaceutical processing.

**Tissue Engineering and Regenerative Medicine:** Due to its ability to promote the proliferation and survival of various tissue cells-including muscle, bone, and cartilage-IGF-1 LR3 is utilized in research areas such as stem cell culture and tissue repair.

**Experimental Research and Exploratory Applications:** In scientific and laboratory settings, IGF-1 LR3 is used to investigate fundamental questions regarding growth factor signaling pathways and metabolic interventions; however, its research applications currently lack support from direct human clinical trial data.

 

 

**Focus Areas in Bodybuilding and Athletic Recovery**

In the realms of fitness and athletic performance, IGF-1 LR3 has garnered attention for its direct anabolic properties. The core rationale is as follows:

**Direct Downstream Signaling:** Unlike Human Growth Hormone (HGH), which requires hepatic mediation to indirectly raise IGF-1 levels, IGF-1 LR3 directly activates IGF-1 receptors in peripheral tissues (such as muscle), resulting in a more direct signaling pathway.

**Promotion of Muscle Protein Synthesis:** In L6 rat myoblast models, IGF-1 LR3 has been shown to significantly stimulate protein synthesis. By activating the AKT pathway, it effectively drives anabolic processes within muscle cells.

**Theoretical "Nutrient Partitioning" Effect:** Some theories suggest that using IGF-1 LR3 post-workout capitalizes on the window of upregulated GLUT4 transporters in muscle cells, thereby facilitating the targeted delivery of amino acids and glucose to muscle tissue.

**Usage Cycles and Dosages:** Limited available information suggests a typical dosage framework of 20–40 μg daily, administered via subcutaneous or intramuscular injection, followed by a break of equal duration after a 4–6 week cycle to prevent receptor downregulation. It must be emphasized that this dosage information stems from informal discussions and industry forums rather than medical advice based on rigorous clinical research. Important Warning: The World Anti-Doping Agency (WADA) explicitly classifies IGF-1 and all its analogues as S2 prohibited substances; they are banned both in-competition and out-of-competition. Additionally, one must be fully aware of the potential links between the IGF-1 pathway, the risk of hypoglycemia, and certain hormone-sensitive tumors.

 

 

Storage and Usage Instructions (For Research Use)
Storage Conditions: Lyophilized powder should be stored at -20°C; under these conditions, it remains stable for over 24 months. Avoid repeated freeze-thaw cycles.

Reconstitution: It is recommended to reconstitute the lyophilized powder with sterile water for injection to a concentration of 100–200 μg/mL. Swirl gently to dissolve; do not vortex.

Aliquot and Storage: After reconstitution, aliquot into single-use portions and store at -20°C. The solution is stable at 4°C for approximately 7–10 days but should be used as soon as possible.

Usage Restrictions: This product is intended solely for scientific research, laboratory, and manufacturing use; direct administration to humans is strictly prohibited.

 

 

Why Choose Us
1. Direct Manufacturer – No Middleman Markups
We are an integrated manufacturer handling R&D, synthesis, and purification. We control the entire process-from raw amino acids to the finished lyophilized powder-eliminating intermediary markups to provide customers with genuine factory-direct pricing and quality assurance.
2. Professional Production Equipment and Processes
Equipped with automated solid-phase peptide synthesis (SPPS) lines, preparative HPLC purification systems, and lyophilization equipment. Every batch undergoes dual testing via HPLC and mass spectrometry (MS) to ensure sequence accuracy and impurity control.
3. Stable Supply and Ample Production Capacity
With our own production lines and large-scale raw material reserves, we support stable supply ranging from milligram to kilogram scales. Reliable lead times ensure that customer R&D and production schedules remain unaffected by raw material fluctuations.
4. High Purity and Consistent Quality
Standard purity is ≥98% (customization to ≥99% available). Each batch comes with a Certificate of Analysis (COA); minimal batch-to-batch variation ensures the reproducibility of research and application data. 5. Guaranteed After-Sales Support
A professional technical team provides support regarding reconstitution, storage, and application protocols. We ensure timely responses to product inquiries, offer batch traceability and product replacement guarantees, and strive to build long-term, reliable partnerships with our customers.

 

 

FAQ
Q: Where are your products manufactured?
A: Our products originate from Shenzhen, China.
Q: What is the minimum order quantity (MOQ)?
A: The minimum order quantity is 10 bottles/sets.
Q: How soon do you ship?
A: Orders for in-stock items are shipped within 24 hours.
Q: What purity levels do you offer?
A: The standard purity is 99%.
Q: Which shipping carriers do you use?
A: Options include FedEx, DHL, UPS, and postal services.
Q: How long does shipping take?
A: Approximately 10–15 days.
Q: Can you provide COA (Certificate of Analysis) and HPLC (High-Performance Liquid Chromatography) reports?
A: Yes, these are available; all products undergo professional testing prior to shipment.
Q: Do you offer OEM/private labeling services?
A: Yes, OEM/private labeling services are available, subject to minimum order quantity requirements.
Q: How is after-sales service handled?
A: If a quality issue caused by our production process is confirmed after the customer receives the goods, we offer free replacement or a refund. We uphold a pragmatic and responsible service philosophy, actively responding to and properly resolving all issues without evasion or excuses, while fully safeguarding our customers' interests.
Q: What payment methods do you accept?
A: We accept bank transfers, Bitcoin, TransferWise, and Xoom.

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