5-Amino-1MQ is a small-molecule selective inhibitor, not a peptide, and is a popular research tool in the field of metabolism. With its excellent targeting specificity for NNMT and very low off-target interference, it is ideally suited for dissecting cellular methyl metabolism and energy homeostasis pathways. Many research groups use this ingredient when studying adipocyte metabolism, NAD⁺ regulation, and aging-related mechanisms. This product is for in vitro laboratory research only and is prohibited for human, clinical, and aesthetic applications.
Main Functions:
Remodeling Lipid Metabolism: By inhibiting NNMT, it reduces the volume of white adipocytes and promotes lipid oxidation, reducing fat accumulation without suppressing appetite.
Boosting Cellular Energy: Increases NAD+ levels, improves mitochondrial function, enhances physical endurance, and accelerates post-exercise recovery.
Improving Metabolism and Anti-Aging: Improves insulin sensitivity, reduces systemic inflammation, and supports DNA repair, potentially delaying cellular aging.
Suitable Scenarios
To be honest, if you've tried various weight loss methods but are stuck at a plateau, especially with stubborn fat that makes you gain weight even from drinking water, or if you often feel tired and lack energy and are looking for a way to boost metabolism at the cellular level, then this is indeed a very attractive option. Many fitness enthusiasts or anti-aging enthusiasts use it for body restructuring. However, we must be clear: this product has not yet been approved by the FDA, and most of the evidence comes from mouse experiments, lacking real human clinical data. Therefore, it currently belongs more to the realm of "cutting-edge biohacking" exploration. Don't treat it as a panacea, and certainly don't expect it to replace a healthy diet and exercise.
Storage Conditions
Freeze-dried powder (research grade): -20℃, protected from light, stable for 12–24 months; 2–8℃, short-term storage for several weeks. Small molecules are more durable than peptides, but clumping after moisture absorption will affect weighing accuracy. Desiccant included.
Oral capsules (grey market product): Store in a cool, dry place away from light (15–25°C). Do not place in the bathroom or near a car window. Quaternary ammonium salts are generally not easily degraded, but the capsule shell may become sticky if damp.
Reconstitute (subcutaneous use): Slowly push sterile water/physiological water along the wall, gently roll, and use within 7–14 days at 2–8°C, away from light. Do not freeze-thaw the solution (although small molecules are not easily damaged by freezing, repeated freeze-thaw cycles can cause crystal form changes). A colorless and clear solution is normal; discard if cloudy.
Weigh using an analytical balance and a low-absorption tube; do not use a kitchen scale to estimate a "spoonful".
Note: 5-amino-1MQ has a quaternary ammonium structure, is reasonably water-soluble but pH sensitive; do not use strong acids or bases to adjust the reconstitution.
Precautions:
Pour cold water first: This molecule is a typical example of "good data in mice, zero data in humans, and a prime target for grey market products". Sinclair's *Aging 2020* paper presents data on 5-amino-1MQ in mice over 4–12 weeks. It fails to address whether this can be replicated in humans, or whether long-term methylation perturbations will have adverse effects (NNMT itself is highly expressed in liver cancer, and inhibiting it can actually promote growth in some tumor models-a contradictory signal).
The biggest pitfall in this gray market: the actual content of the claimed 50mg capsules, whether it's mixed with MNA itself, and whether there are synthetic residues (quinolinamine intermediates are toxic). The Certificate of Authorization (COA) is usually self-printed. If you're going to get involved, at least look for third-party reports with HPLC/MS; don't believe the "pharmaceutical grade" rhetoric.
Dosage is entirely based on mouse dosage conversion (10 mg/kg in mice → approximately 1.6 mg/kg subcutaneously in humans, or 50–100 mg/day orally as per community guidelines). No one uses safety window data; the long-term effects of liver methylation load and global SAM changes are unknown.
Possible side effects: headache, mild nausea, shallow sleep (SIRT1 affects diurnal rhythm in some individuals after NAD system activation), occasional palpitations; individuals with liver disease or methylation sensitivity (MTHFR mutation, high homocysteine levels) should not attempt this, as NNMT inhibition will affect the global SAM pool.
Avoid during pregnancy/breastfeeding, for minors, those with a history of cancer, or during periods of autoimmune activity.
WADA strictly enforces this policy; avoid bodybuilding/powerlifting/triathlon.
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