It's a double-modified version of the classic pineal tetrapeptide Epithalon (Ala-Glu-Asp-Gly)-N-terminal acetylation + C-terminal amidation (Ac-AEDG-NH₂). Simply put, it adds two layers of "anti-degradation armor" to the original, making it more stable, less prone to enzymatic breakdown, and better absorbed than regular Epithalon.
Core Functions:
Stimulates the body to secrete melatonin, regulates disordered circadian rhythms, improves sleep quality, and alleviates shallow sleep and frequent awakenings caused by staying up late and aging.
Activates telomerase activity, protects telomere length, slows down cell aging, and reduces premature cell death and apoptosis.
Balances systemic endocrine levels, alleviates hormonal imbalances that occur with age, and improves fatigue and slowed metabolism caused by aging.
Weakens chronic low-grade inflammation, eliminates excess free radicals, reduces oxidative damage, and slows down the aging process of skin and organs.
Key Advantages
Dual modification with acetyl + amide makes it more resistant to enzymatic degradation in vivo compared to ordinary epitalons, resulting in longer in vivo retention and more pronounced effects at the same dosage.
Clear and specific target: Primarily acts on the pineal gland and telomere-related pathways, with minimal interference from other hormones, resulting in clean and stable experimental data.
Wide range of applicable experimental models: Can be used in cell culture and mouse aging models without the need for additional reagents.
High tolerability: Rarely exhibits abnormal stress responses in animal experiments; long-term administration shows higher survival rates.
Storage Conditions
Lyophilized powder (unopened): Long-term storage at -20℃ or -80℃, protected from light and dry, stable for 2 years; short-term storage (≤6 months): Refrigerate at 2~8℃.
Reconstituted solution: Refrigerate at 2~8℃, protected from light. Recommended use within 7~30 days. Repeated freeze-thaw cycles are strictly prohibited.
White or off-white powder, readily soluble in water/physiological saline. When preparing a solution, slowly pour along the bottle wall and gently rotate to dissolve; avoid vigorous shaking.
Precautions
Tumor Risk Theory Controversy:
Telomerase activation has been mentioned in in vitro studies. Use with caution/avoid use in individuals with active malignant tumors or high-risk groups.
Side Effects are rare but exist: Mild injection site pain or transient headaches are occasionally reported; allergic reactions are rare.
Long-term continuous use is not recommended: Refer to the Khavinson regimen-10-20 days per course, followed by a several-month break before resuming the cycle. Usually used at night to align with the melatonin rhythm.
Contraindicated in pregnant women, breastfeeding mothers, and minors (safety data lack).
A reminder-this is for research purposes only, not an approved drug. Do not use it as a health supplement for long-term oral or injectable purposes. If you must use it, consult a doctor knowledgeable in peptides for evaluation.
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Second, we will provide a quotation based on your needs or our suggestions.
Third, the customer confirms the sample and pays a deposit.
Fourth, we will arrange production. Discounts are available for bulk orders.
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Therefore, we implement strict quality control before shipping. If any quality issues are found to be caused by us, we will replace the product free of charge or provide a refund.
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