This is a short-chain polypeptide with a molecular weight of approximately 487.5 Da. Research focuses on its ability to penetrate the nucleus of prostate cells, interact with chromatin, and loosen the heterochromatin contraction caused by age, thereby reactivating the expression of ribosomes and related genes. It is a core observation target in the field of prostate biological regulation, primarily targeting the decline in prostate function due to aging.
Core Advantages and Functions (Based on Preclinical/In vitro Studies)
Chromatin Decondensation and Gene Reactivation: In experiments with aging lymphocytes and prostate epithelial cells, it can promote the relaxation of 30 nm chromatin fibers into 10 nm filaments, enhance the activity of the nucleolar tissue region, and bring back silent protein synthesis-related genes, thus slowing down the cellular aging process at the epigenetic level.
Anti-inflammatory and homeostatic effects on the prostate: In animal models of chronic nonbacterial prostatitis, it can suppress pro-inflammatory factors such as TNF-α and IL-6, reducing edema, vascular congestion, and immune infiltration. It can also inhibit abnormal proliferation of epithelial and stromal tissues, helping to maintain the normal glandular renewal rhythm and preventing fibrosis and sclerosis.
Antioxidant and tissue protection: It can directly scavenge some reactive oxygen species (ROS), protecting DNA and mitochondria from oxidative damage. It provides some stress relief to cells in the local prostate microenvironment, acting as a supplementary buff.
High tissue specificity and structural stability: As a tetrapeptide with a proline residue, its signal targeting the prostate is relatively clean, avoiding indiscriminate targeting. Synthetic purity is easily controlled (typically ≥98%–99%), and its small molecular weight allows for good penetration, making it convenient for cell and small animal experiments.
Storage Conditions
Freeze-dried powder (undiluted): Long-term storage must be at -20 °C or lower (some strict labs store at -70 °C), protected from light and in a dry place. Moisture control is crucial. Unopened, it generally lasts 24 months. For short-term storage, it can be refrigerated at 2–8 °C for a few months, but avoid frequently opening and closing the bottle to allow moisture in.
After reconstitution (after dilution): It is recommended to aliquot and store at 2–8 °C. Absolutely avoid repeated freeze-thaw cycles, as the peptide chains will collapse after a few cycles. Use within 2–4 weeks after reconstitution. Discard immediately if cloudy, discolored, or with floating matter.
Handling details: Weighing should be done in a dry environment. Reconstitution uses sterile water or buffer solution. Gently swirl/roll along the wall, avoiding vigorous shaking that creates bubbles. Before opening, allow the tube to reach room temperature to prevent condensation from entering and spoiling the powder.
Finally, as someone knowledgeable in this field, I must sincerely advise: this is a research-grade peptide, not something you can just buy and use as a guinea pig. Everyone's physical condition is different, and prostate problems may hide other risks. Before deciding to try it, please, please consult a professional doctor for a comprehensive evaluation. We should strive for a high-quality life, but safety should always be the bottom line!
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