Mastolide is a domestically produced dual-target peptide that simultaneously activates GLP-1 and glucagon receptors. It's commonly used in both clinical weight loss and blood sugar control, as well as in laboratory metabolic research. Unlike single-target GLP-1 formulations, it simultaneously controls appetite and promotes fat breakdown, making it particularly effective for obese individuals, those with abnormal blood sugar, and those with fatty liver. It's available in both medical injectable formulations and research-grade lyophilized powder.
Its core advantage lies in its "two-pronged approach": firstly, by activating GLP-1 receptors to suppress appetite and slow gastric emptying, you naturally eat less; secondly, it activates GCG receptors, directly promoting liver fat breakdown and enhancing energy expenditure. In short, it not only effectively reduces weight but also specifically targets troublesome "belly fat" and fatty liver, while also effectively regulating blood sugar and blood lipids. Clinical data is particularly impressive, with weight loss effects comparable to or even surpassing some international brands, and a lower probability of discontinuation due to side effects, making it quite suitable for the physique of Asians.
Storage Conditions
Unopened: Store in a cool, dark place, sealed, refrigerate at 2-8°C (fresh compartment only). Do not freeze (discard immediately if frozen).
Short-term room temperature: The original packaging can be stored at 10-30°C for no more than 30 days. Once removed from the refrigerator, do not return it. Discard any unused medication after the expiration date.
Inspect the medication solution before use-do not administer if it is cloudy, discolored, or contains particles.
Precautions & Contraindications
Absolutely contraindicated in: hypersensitivity to any component, personal/family history of medullary thyroid carcinoma (MTC), MEN type 2 multiple endocrine neoplasia syndrome, pregnancy (discontinue medication at least 3 months prior to conception), and breastfeeding.
Common side effects: nausea, vomiting, diarrhea, abdominal distension, dizziness, redness and swelling at the injection site-often occur during dose escalation and generally lessen over time. If persistent, severe abdominal pain occurs (be alert for pancreatitis), or if there is a neck mass/difficulty swallowing (thyroid problem), seek immediate medical attention.
Preoperative Information: Inform the anesthesiologist that you are using this type of medication before general anesthesia or deep sedation (delayed gastric emptying → risk of aspiration).
Concomitant Use Precautions: When used concurrently with insulin/sulfonylurea hypoglycemic agents, be wary of hypoglycemia; dosage reduction may be necessary. Monitor heart rate; if resting heart rate remains significantly elevated, consult a doctor for evaluation.
Not Recommended: Use with caution or avoid use in patients with moderate to severe hepatic or renal insufficiency, or a history of pancreatitis/cholelithiasis. Safety has not been established in patients under 18 years of age.
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