Product Introduction:
Iparrelin is a novel, highly selective growth hormone-releasing peptide (GHRP), belonging to the synthetic pentapeptide class of compounds. Originally developed by Novo Nordisk in the 1990s, it aims to promote the natural secretion of human growth hormone (GH) by mimicking the action of ghrelin on the pituitary gland. As the third-generation representative of the GHRP family, iparelin, with its unique molecular structure, low risk of side effects, and highly selective receptor agonist activity, is widely used in anti-aging, post-exercise recovery, lipid metabolism regulation, and endocrine function research.
1. Classification System
From the perspective of raw materials and applications, iparelin can be divided into the following three main categories:
**Pharmaceutical Grade** This type of iparelin has extremely high purity, typically exceeding 99%, and meets GMP production standards. It is mainly used in clinical research, drug development, and high-end medical anti-aging projects. Pharmaceutical-grade products have strict impurity control and stability verification, as well as excellent solubility and batch-to-batch consistency.
**Research Grade** Purity is generally between 95% and 98%, primarily supplied to research institutions, laboratories, and biotechnology companies for cell or animal experiments. Its production process is similar to pharmaceutical grade, but quality control standards are slightly lower, making it suitable for exploring the physiological functions, pharmacokinetic characteristics, and potential clinical applications of iparrelin.
**Cosmetic/Nutritional Grade** These products are mainly used in the beauty and health care and sports nutrition fields, such as anti-aging creams, muscle-building supplements, or topical repair peptide preparations. Purity is typically maintained above 90%, and some products undergo lyophilization to improve storage stability.
2. Molecular Structure and Chemical Properties
Iparrelin is a synthetic pentapeptide with the molecular formula C₃₈H₄₉N₉O₅ and a molecular weight of approximately 711.86 g/mol. Its amino acid sequence is: Aib-His-D-2-Nal-D-Phe-Lys-NH₂.
The introduction of α-aminoisobutyric acid (Aib) and D-2-naphthylalanine (D-2-Nal) endows iparene with excellent steric stability and receptor affinity. This structure gives iparene potent growth hormone-releasing activity while stimulating almost no cortisol or prolactin secretion, exhibiting excellent selectivity.
Iparene is a white or off-white amorphous powder, a hydrophilic polypeptide, readily soluble in water, acetate buffer, and dilute ethanol. Its isoelectric point (pI) is approximately 6.5, indicating a neutral to weakly basic pH. This compound is sensitive to temperature and light; high temperatures and strong light exposure should be avoided. It is stable for 12 to 24 months in the lyophilized state, while short-term storage in solution is recommended at 2–8°C.
3. Appearance and Color Characteristics
High-quality iparene raw material powder is a white to off-white fine crystalline powder with a loose texture, good flowability, and slight hygroscopicity. No visible impurities or lumps should be observed. Slight yellowing or grayish-white discoloration usually indicates excessive humidity during storage or oxidation. High-purity products are freeze-dried under vacuum to obtain uniform powder particles. After dissolution, a clear or slightly milky-white solution should be formed, without precipitation or foam.
4. Pharmacological Actions and Mechanisms
The main mechanism of action of iparrelin is through selective activation of growth hormone secretion receptors (GHS-R1a) in the anterior pituitary gland and hypothalamus. Its pathway of action differs from direct supplementation of exogenous growth hormone; instead, it stimulates the release of naturally produced growth hormone, thereby maintaining physiological hormonal rhythms.
1. Promotes Growth Hormone Secretion
Iparrelin can significantly increase plasma growth hormone (GH) concentrations. Animal studies have shown that GH levels rise rapidly within 15 to 30 minutes after administration and return to baseline levels within 1 hour. The increase in GH levels is positively correlated with the dose but does not lead to excessive secretion.
2. Promotes Lipid Metabolism and Lean Body Mass Increase
Promoting growth hormone secretion helps with fat mobilization, increases energy expenditure, and promotes muscle protein synthesis. Iparrelin is commonly used in bodybuilding, rehabilitation, and body reshaping to improve body fat percentage, increase muscle density, and restore metabolic vitality.
3. Improves Sleep and Delays Aging
Studies have shown that iparelin can indirectly improve deep sleep (slow-wave sleep), promote cell repair and collagen production, and has potential benefits for skin firmness, mental state, and anti-aging.
4. Protects the Cardiovascular and Metabolic Systems
Unlike early GHRP-6 or GHRP-2, iparelin does not cause a strong feeling of hunger or an increase in cortisol, therefore it has almost no negative impact on blood sugar, blood pressure, and cortisol levels, and exhibits higher metabolic stability.
5. Performance Advantages
Compared to similar growth hormone-releasing peptides (such as GHRP-2, Hexarelin, GHRP-6, etc.), iparelin has the following advantages:
High Selectivity: It acts only on the growth hormone secretion pathway and has no significant effect on adrenocorticotropic hormone, cortisol, or prolactin.
Mild side effects: No significant hunger, no water or sodium retention, and no hyperglycemic effect.
Short half-life and strong rhythmicity: The half-life is approximately 2 hours, mimicking the natural pulse-like release rhythm of growth hormone in the human body.
Good tolerability: Multiple injections do not cause desensitization reactions, resulting in low physiological burden.
Good stability: The lyophilized powder is stable at low temperatures, and the solution remains clear after reconstitution, maintaining a high activity retention rate.
6. Physical stability and storage requirements
Iparreline powder exhibits good stability under dry, light-protected conditions. The recommended storage temperature is 2–8°C. Long-term storage can be carried out at -20°C. Repeated freeze-thaw cycles should be avoided in solution form to prevent peptide chain breakage or decreased activity. Its pH stability range is 5.0 to 7.5, within which structural stability and biological activity are maintained. For research or clinical applications, it is usually prepared by vacuum lyophilization and reconstituted into a sterile injection solution before use.
7. Testing and Quality Control
High-quality ipareline raw materials require rigorous testing. Common testing methods include:
High-Performance Liquid Chromatography (HPLC): Detects purity and impurity peak areas.
Mass Spectrometry (MS): Confirms molecular weight and chemical structure.
Infrared Spectroscopy (IR): Verifies chemical bond characteristics.
Amino Acid Sequence Analysis: Confirms peptide chain integrity.
Bioactivity Testing: Verifies growth hormone-releasing activity through cell models or animal experiments.
These tests ensure the consistency of chemical and biological activity in each batch of product and are indispensable quality standards for pharmaceutical-grade raw materials.
How to Order?
First, please inform us of your needs or application scenario.
Second, we will provide a quotation based on your needs or our suggestions.
Third, the customer confirms the sample and pays a deposit.
Fourth, we are responsible for arranging production. Discounts are available for bulk orders.
How is the quality of your products? First, our product quality is excellent and stable. We conduct 100% testing before shipment.
Therefore, we conduct strict quality control before shipment. If any quality issues are found to be caused by us, we will replace the product or provide a refund free of charge.
How to build a long-term, positive partnership with us?
1. We insist on providing high-quality products and competitive prices to ensure customer benefits;
2. We respect every customer, treat them as friends, and sincerely do business and make friends with them, no matter where they come from.
Hot Tags: Peptide drugs for bodybuilding Ipamorelin 2mg/vial, China Peptide drugs for bodybuilding Ipamorelin 2mg/vial manufacturers, suppliers, factory
