Mechanism of Action
Alprostadil binds to prostaglandin receptors and activates adenylate cyclase, thereby increasing intracellular cyclic adenosine monophosphate (cAMP) levels; this leads to smooth muscle relaxation and vasodilation. In the corpus cavernosum tissue, this mechanism relaxes smooth muscle and dilates cavernosal arteries, increasing local blood flow. Through the "veno-occlusive mechanism," it compresses the subtunical veins, thereby achieving and maintaining an erection.
In vitro studies have confirmed that Alprostadil relaxes human cavernosal smooth muscle and arterial segments pre-contracted by norepinephrine or PGF2α; in vivo, it increases cavernosal arterial blood flow in a dose-dependent manner.
Applications
1. Clinical Medical Applications
Treatment of Erectile Dysfunction (ED): Alprostadil is the only FDA-approved drug for intracavernosal injection to treat ED; it is indicated for patients who do not respond to or cannot tolerate oral PDE5 inhibitors. Administration methods include intracavernosal injection (e.g., Caverject, Edex) and intraurethral suppositories (e.g., MUSE).
Ductus Arteriosus-Dependent Congenital Heart Disease in Neonates: Continuous intravenous infusion is used to maintain the patency of the ductus arteriosus, ensuring pulmonary or systemic blood flow until surgical intervention.
Peripheral Vascular Disease and Microcirculation Improvement: Leveraging its vasodilatory and anti-platelet aggregation properties, it is used as an adjunctive therapy for microcirculatory disorders such as diabetic peripheral neuropathy and diabetic nephropathy.
2. Bodybuilding Context
In the field of bodybuilding, Alprostadil is used by some athletes for "site enhancement" (local muscle enlargement). By directly injecting the drug into small muscle groups-such as the biceps or calves-prior to competition, users induce local vasodilation and temporary tissue swelling to create the visual effect of fuller muscles.
It must be noted that this application is temporary and cosmetic in nature; it is unrelated to training-induced muscle hypertrophy and carries significant risks. From a professional standpoint, Alprostadil has limited actual value in bodybuilding and should not be considered a performance-enhancing drug.
Storage and Usage Instructions
Storage Conditions
Powder form: Store at -20°C in a sealed container, protected from light and moisture. Stable for over 2 years under these conditions.
Shipping conditions: Can be shipped at room temperature; the product remains stable during standard shipping durations.
After reconstitution: If prepared as a solution, use within 24 hours; store between 2°C and 25°C; do not freeze.
Usage Instructions
Intracavernosal injection: The initial dose is typically 2.5 mcg; the first administration should be performed by a healthcare professional in a clinical setting to determine the individualized dosage. The effective dose range is 2.5 to 60 mcg, with a maximum frequency of three times per week and a minimum interval of 24 hours between doses. Inject into the lateral aspect of the penile corpus cavernosum, avoiding the urethra and the dorsal neurovascular bundle.
Urethral suppository: The recommended initial dose is 500 mcg, inserted into the urethra immediately after voiding; the maximum dose is 1000 mcg, not to exceed two doses within 24 hours.
Important safety note: Erection duration should not exceed 1 hour. If an erection lasts longer than 3 hours, seek immediate medical attention to prevent permanent damage to the corpus cavernosum.
Why Choose Us
As a professional supplier of Alprostadil raw materials, we offer the following core advantages:
Direct manufacturer with cost control: We own our production facilities and manage the entire supply chain-from raw materials to finished products-eliminating intermediaries to offer competitive prices.
Professional equipment and mature processes: Equipped with specialized reaction systems (ultra-low temperature, high pressure, high vacuum) and possessing full capabilities ranging from laboratory R&D to commercial production, ensuring batch-to-batch consistency.
Superior purity and stable quality: Verified by HPLC with purity ≥99%; strict control of related substances (e.g., PGA1, PGB1) ensures compliance with USP/EP standards.
Reliable supply and timely delivery: Ample production capacity allows for flexible shipping schedules tailored to customer needs, supporting global distribution.
Comprehensive after-sales support: Full technical documentation (COA, MSDS) provided; a professional team is available to address technical inquiries and quality feedback.
FAQ
Q: Where are your products manufactured? A: Our products originate from Shenzhen, China.
Q: What is the minimum order quantity (MOQ)?
A: The MOQ is 10 bottles/sets.
Q: How soon do you ship?
A: Orders for in-stock items are shipped within 24 hours.
Q: What purity levels do you offer?
A: The standard purity is 99%.
Q: Which shipping carriers do you use?
A: Options include FedEx, DHL, UPS, and postal services.
Q: How long does shipping take?
A: Approximately 10–15 days.
Q: Can you provide COA and HPLC test reports?
A: Yes; all products undergo professional testing before shipment.
Q: Do you offer OEM services?
A: Yes, OEM services are available, subject to MOQ requirements.
Q: How do you handle after-sales issues?
A: If a quality issue caused by our production is confirmed after the customer receives the goods, we offer free replacements or refunds. We are committed to a pragmatic and responsible service approach, actively addressing and resolving issues without evasion or excuses, while fully protecting our customers' interests.
Q: What payment methods do you accept?
A: We accept bank transfers, Bitcoin, TransferWise, and Xoom.
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