Methods of Administration (Key Points)
Route: Daily aqueous injection → subcutaneous injection in the abdomen/thigh; sustained-release microspheres/suspension → deep intramuscular injection in the buttock (Trelstar limited to IM, do not mix IV/SC).
Prostate Cancer (Androgen Deprivation): 3.75 mg IM/SC every 4 weeks; or 11.25 mg/12 weeks; or 22.5 mg/24 weeks. Anti-androgens (bicalutamide/cyproterone acetate) can be used to cover the flare-up 2–4 weeks before the first dose to prevent worsening of bone pain, urinary tract obstruction, and spinal cord compression.
Endometriosis/Uterine Fibroids: Starting from day 1–5 of the menstrual cycle, 3.75 mg every 4 weeks for 3–6 months (a second course is not recommended); add-back estrogen and progesterone can be used to alleviate hypoestria symptoms.
Central precocious puberty (CPP): 50 μg/kg body weight every 4 weeks (or 11.25 mg/12 weeks, 22.5 mg/24 weeks), discontinue when bone age is ≥12 years for girls and ≥13 years for boys.
Assisted reproduction (pituitary downregulation): Dapoxetine 0.1 mg SC daily, or mid-luteal long-acting gonadotropin 1.875–3.75 mg once daily, until estrogen levels reach target levels, then initiate gonadotropin.
Monitoring: Testosterone/estradiol ratio, LH/FSH ratio, bone mineral density (mandatory for >6 months of treatment), prostate symptoms, blood glucose, and blood lipids; women should use non-hormonal contraception for the first month of treatment, and start medication after ruling out pregnancy.
Contraindications: Pregnancy (Category X), hypersensitivity to GnRH analogs, non-hormone-dependent prostate cancer, castrated (surgical/medical) prostate cancer, active osteoporosis, progressive brain tumors (children).
Application Scenarios:
1. FDA-Approved Indications:
Advanced Prostate Cancer: Triptorelin is a first-line option for androgen deprivation therapy (ADT), inhibiting the proliferation and metastasis of androgen-dependent prostate cancer cells by lowering serum testosterone to castration levels.
2. Widespread Clinical Applications (Off-label/Global Registration):
Central Precocious Puberty (CPP): Used to inhibit premature activation of the hypothalamus-pituitary-gonadal axis, delaying bone age progression and protecting final adult height.
Endometriosis: Induces a hypoestrogenic state (pseudomenopause), inhibiting the growth of ectopic endometrial lesions and relieving pain symptoms.
Uterine Fibroids: Reduces fibroid volume preoperatively, decreasing intraoperative bleeding; or used for conservative treatment of patients with anemia.
Assisted Reproductive Technology (ART): Used in IVF cycles for down-regulation to prevent premature LH surges and achieve synchronized control of follicle development.
Breast Cancer: Used for ovarian castration treatment of hormone receptor-positive premenopausal breast cancer.
Storage Conditions:
To ensure the physical structure of the microsphere formulation and the bioactivity of the peptides, triptorelin has strict storage requirements: Unreconstituted (lyophilized powder/microspheres): Must be stored in a refrigerated environment at 2°C to 8°C (36°F to 46°F), protected from light and moisture. Freezing is strictly prohibited to avoid damaging the sustained-release structure of the microspheres.
Reconstituted (suspension): The reconstituted solution must be used immediately and cannot be stored or reused.
Transportation Requirements: Cold chain equipment should be used during transportation, avoiding severe vibration and direct sunlight.
FAQ
Q: What is the minimum order quantity?
A: The minimum order quantity is 10 bottles/set.
Q: How long does it take to ship? A: In-stock orders will be shipped within 24 hours.
Q: What purity level can you provide?
A: Standard purity 99%.
Q: Which courier service do you use?
A: FedEx, DHL, UPS, and postal services are available.
Q: How long does shipping take?
A: Approximately 10-15 days.
Q: Can you provide a COA (Certificate of Account) quality inspection report and HPLC (High-Performance Computing) report?
A: Yes, all goods undergo professional testing before shipment.
Q: Do you support OEM branding?
A: OEM branding is supported, subject to minimum order quantity requirements.
Q: What are your after-sales service terms?
A: After the customer receives the goods, if the quality problem is confirmed to be caused by our production, they can enjoy free replacement or refund. We adhere to a pragmatic and responsible service principle, actively responding to and properly handling all kinds of issues, without shirking responsibility or avoiding problems, and fully protecting customer rights.
Q: What payment methods are available?
A: We support bank transfer, Bitcoin, Transferwise, and Xoom.
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