Methods of Application
The clinical application of Gonadorelin is mainly divided into two methods: single intravenous injection and pulsatile microinfusion:
* Single Intravenous Injection (Provocation Test): Reconstituted with sterile saline before use. The usual single dose is 25 μg for women and 100 μg for men. Venous blood is drawn before injection (0 minutes) and at 25, 45, 90, and 180 minutes after injection to assess pituitary function by measuring serum LH and FSH concentrations.
* Pulsatile Subcutaneous/Intravenous Infusion (GnRH Pump Therapy): For specific diseases, a microinfusion pump is used to simulate the physiological pulsatile secretion of the hypothalamus. Commonly used drug concentrations are 100-500 μg/ml, and the pulse frequency is usually set to once every 60-90 minutes to continuously stimulate the pituitary-gonadal axis.
* Application Scenarios
Gonadorelin is primarily used clinically for the diagnosis of endocrine disorders and the treatment of specific reproductive problems:
* **Hypothalamic-Pituitary Function Assessment:** As a differential diagnostic tool, it is used to assess male or female fertility disorders, amenorrhea (e.g., galactorrhea, primary/secondary amenorrhea), gonadal atrophy, and gonadal insufficiency caused by hypothalamic or pituitary hypofunction.
* **Ovulation Induction and Fertility Treatment:** Continuous administration via a pulsed pump can promote and maintain the development of secondary sexual characteristics in patients with hypothalamic amenorrhea (IHH) or constitutional delayed puberty (CDP), restoring normal physiological regulation and fertility.
* **Other Endocrine Regulation:** In some clinical studies, it has also been used for menstrual cycle regulation and fertility induction in non-obese polycystic ovary syndrome (PCOS).
Storage Conditions
Gonadorelin is a polypeptide, and its molecular structure is sensitive to environmental factors. Therefore, the following storage guidelines must be strictly followed:
Unreconstituted (lyophilized powder): Store in a cool, dark, and tightly closed container at 2°C to 8°C (36°F to 46°F). Freezing is strictly prohibited. Some manufacturers' instructions may specify storage at room temperature below 25°C; please refer to the actual product instructions for specific guidelines.
Reconstituted (solution): The prepared solution is highly susceptible to degradation and must be stored in a cool, dark environment at 2°C to 8°C. To ensure drug potency and sterility, the reconstituted solution should generally be used within 24 hours.
FAQ
Q: What is the minimum order quantity?
A: The minimum order quantity is 10 bottles/set.
Q: How long does it take to ship?
A: In-stock orders will be shipped within 24 hours.
Q: What purity levels can you provide?
A: Standard purity 99%.
Q: Which courier service do you use?
A: You can choose FedEx, DHL, UPS, or postal services.
Q: How long does shipping take?
A: Approximately 10-15 days.
Q: Can you provide a COA (Certificate of Account) quality inspection report and HPLC (High-Performance Computing) report?
A: Yes, all goods undergo professional testing before shipment.
Q: Do you support OEM branding?
A: We support OEM branding services, subject to minimum order quantity requirements.
Q: What are your after-sales service details?
A: After the customer receives the goods, if the quality problem is confirmed to be caused by our production, they can enjoy free replacement or refund. We adhere to a pragmatic and responsible service principle, actively responding to and properly handling all kinds of issues, without shirking responsibility or avoiding problems, and fully protecting customer rights.
Q: What payment methods are available?
A: We support bank transfer, Bitcoin, Transferwise, and Xoom.
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