ARA-290 (also known as Cibinetide) is a synthetic 11-peptide derived from the B-helix region of erythropoietin (EPO). It selectively activates the innate repair receptor (IRR = EPOR/CD131 heteromer), retaining the anti-inflammatory, neuroprotective, and tissue-repairing effects of EPO, but completely eliminating its erythropoietic (hematopoietic) activity-injecting it will not increase blood cell count or the risk of thrombosis.
Its core function and advantages truly address a key challenge in many neurological disease research areas. As a specific agonist of the innate repair receptor (IRR), it not only possesses potent anti-inflammatory and anti-apoptotic properties but also promotes angiogenesis. In animal experiments, it not only improves glycemic control in diabetic rats but also significantly reduces neurological damage in a multiple sclerosis (EAE model). For researchers studying neurodegenerative diseases or ischemic injuries, this peptide, which protects cells without increasing blood viscosity, is an invaluable tool.
Storage Conditions: The lyophilized powder must be tightly capped, completely protected from light, and kept dry. For long-term storage, aliquot and freeze at -20°C. Do not repeatedly freeze and thaw, as this easily inactivates the peptide chains; no visible change in appearance will occur, but the activity will be completely lost.
Prepared aqueous solutions should be refrigerated at 2-8°C and used as soon as possible, not exceeding 28 days. Keep away from windowsills, high-temperature equipment, and humid environments. Store separately, labeled, and do not mix with other peptides.
Precautions: Strictly prohibited for human use: Research grade is for in vitro/in vivo animal experiments only. Do not inject, take orally, or apply topically to humans-no clinical approval and no safe dosage data available.
Handling Protection: The powder is hygroscopic and harmful if inhaled in small amounts. Wear nitrile gloves and goggles. Weighing/reconstituted is best done in a fume hood. Protect from dust and aerosols.
Reconstitution Method: Slowly add antibacterial water along the wall of the container → gently swirl with your fingertip until clear → mark the reconstitution date; if using DMSO to prepare the stock solution, pay attention to the cytotoxicity of the final concentration.
Disposal: Dispose of as controlled biochemical/chemical waste to a qualified unit; do not pour into sewers.
First Aid: For skin/eye contact, flush with plenty of running water for ≥15 minutes; for inhalation, move to fresh air, seek medical attention if necessary, and indicate that it is a highly active peptide.
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