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Follistatin 344 1mg/via Is Used For Muscle Atrophy And Gene Therapy. CAS: 80449-31-6

Follistatin 344 1mg/via Is Used For Muscle Atrophy And Gene Therapy. CAS: 80449-31-6

Follistatin is a naturally occurring single-chain glycoprotein initially attracted attention for its ability to inhibit the release of follicle-stimulating hormone (FSH). Follistatin 344 is a 344-amino acid isoform produced by alternative splicing of the FST gene. Functionally, Follistatin 344 belongs to the transforming growth factor-β (TGF-β) superfamily of potent binding proteins. Its core mechanism of action lies in its high affinity binding to and neutralization of ligands such as myostatin (GDF-8) and activins. By blocking these ligands, Follistatin 344 effectively blocks their binding to ActRIIB receptors, thereby relieving the negative regulation of muscle growth and differentiation. In preclinical studies, it has shown potential for promoting muscle mass increase and improving muscle function.

Product Introduction

Application Scenarios

Muscle Loss and Regeneration Research: As a natural myostatin antagonist, Follistatin 344 is widely used in mechanistic and intervention studies of disease models such as Duchenne muscular dystrophy (DMD), inclusion body myositis, and age-related muscle atrophy (sarcopenia).

Metabolic Regulation Exploration: Studies have shown that by regulating the activin and myostatin signaling pathways, Follistatin 344 may have a positive impact on insulin sensitivity, glucose uptake, and lipid metabolism, providing a tool for research on metabolic diseases.

Gene Therapy and Cell Therapy: In gene therapy strategies, the use of adeno-associated virus (AAV) vectors to deliver the Follistatin 344 gene sequence for sustained protein expression in vivo is one of the important clinical research directions for the treatment of muscle diseases.

 

 

Storage and Usage Methods

To ensure bioactivity and stability, please strictly follow the following guidelines:

Storage Conditions:

Lyophilized Powder: Recommended storage at -20°C to -70°C. Stable for 12 months from the date of receipt. After reconstitution: For short-term use, store under aseptic conditions at 2-8°C for one month. For long-term storage, it is recommended to aliquot and store at -20°C to -70°C, avoiding repeated freeze-thaw cycles; storage time is up to 3 months.

Usage:

Reconstitution: It is recommended to prepare a 100 μg/mL stock solution using sterile 18MΩ-cm ultrapure water or sterile PBS (phosphate-buffered saline).

Alliance: It is recommended to aliquot according to the single-use quantity to prevent protein activity degradation and aggregation due to repeated freeze-thaw cycles.

Thawing: Remove from the freezer before use and thaw slowly at room temperature. After thawing, briefly centrifuge to collect the liquid at the bottom of the tube.

 

 

Why Choose Us?

Direct Supply Advantage from Source Factory: We are a source factory with mature production lines, possessing full-chain capabilities from R&D to mass production, eliminating intermediaries and ensuring you obtain high-quality products at a more competitive price.

Professional Equipment, Leading Technology: Equipped with internationally advanced production and purification equipment, we strictly adhere to standardized process flows to ensure batch-to-batch consistency and stability of every product.

Ultra-High Quality, Guaranteed Purity: We promise product purity of over 98.5% (HPLC detection), with endotoxin levels below 1 EU/μg, minimizing experimental background interference and ensuring data reliability.

Stable Supply, Worry-Free After-Sales Service: Leveraging our strong production capacity, we can guarantee a continuous and stable supply of stock. We also provide professional technical support and comprehensive after-sales service to safeguard your research throughout the entire process.

 

 

FAQ
Q: Where are you located?

A: Our products are from Shenzhen, China.

Q: What is the minimum order quantity?

A: The minimum order quantity is 10 bottles/set.

Q: How long does it take to ship?

A: In-stock orders will be shipped within 24 hours.

Q: What purity levels can you provide?

A: Standard purity 99%.

Q: Which courier service do you use? A: You can choose from FedEx, DHL, UPS, and postal services.

Q: How long does shipping take?

A: Approximately 10-15 days.

Q: Can you provide a COA (Certificate of Account) quality inspection report and HPLC (High-Performance Computing) report?

A: Yes, all goods undergo professional testing before shipment.

Q: Do you support OEM branding?

A: OEM branding is supported, subject to minimum order quantity requirements.

Q: How is after-sales service handled?

A: After the customer signs for the goods, if it is confirmed that the quality problem is caused by our production, they can enjoy free replacement or refund. We adhere to a pragmatic and responsible service principle, actively respond to and properly handle all kinds of issues, without shirking responsibility or avoiding problems, and do our best to protect the rights and interests of our customers.

Q: What payment methods are available?

A: We support bank transfer, Bitcoin, Transferwise, and Xoom.

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