Full Name: Prostamax / KEDP Peptide
Sequence: Lys-Glu-Asp-Pro (KEDP, tetrapeptide)
Molecular Formula: C₂₀H₃₃N₅O₉, Molecular Weight 487.5 Da
Appearance: White lyophilized powder, readily soluble in water/PBS, acidic polypeptide (pI≈3.8)
Core Mechanism: Epigenetic regulation-loosening heterochromatin, reactivating senescence-silenced genes, repairing the prostate epithelial proliferation/apoptosis balance, anti-inflammatory, inhibiting excessive proliferation
Category: Khavinson bioregulatory peptide (tissue-specific), related to Epithalon, Livagen, Pancragen, and Testagen
Research Team: St. Petersburg Institute of Bioregulation and Gerontology, Russia, led by Professor Vladimir Khavinson (1990–2000) (Year)
Design Logic: Screening active fragments from natural prostate tissue extracts, artificially synthesizing organ-specific short peptides to avoid hormonal side effects and target the prostate
Positioning: Research-grade prostate health peptide; non-pharmaceutical, without FDA/EMA/domestic drug regulatory approval, for research/health purposes only
Core Research Conclusions (Preclinical)
Chronic aseptic prostatitis: Reduces inflammatory factors, alleviates vascular congestion, and relieves pelvic pain
Benign prostatic hyperplasia (BPH): Inhibits excessive epithelial proliferation, reduces prostate volume, and improves urinary flow rate
Aging prostate: Restores youthful gene expression profile and reduces cellular aging signals
Human Data: No large-scale double-blind trials; only small-sample pilot studies (Russia, 2010–2015) showed IPSS score ↓30–40%, nocturia ↓50%, and improved urinary flow rate
Market Status: European and American/Russian research brand (20mg/ IV. Core Parameters
Sequence: Lys-Glu-Asp-Pro (KEDP)
Molecular Weight: 487.5 Da
Purity: Research grade ≥95%, Health grade ≥98%
Dosage Forms: Injection (20mg/vial), Oral (10mg/capsule), Sublingual (5mg/tablet)
Bioavailability: Injection ≈90%, Sublingual ≈30%, Oral ≈10%
Targets: Prostatic epithelial cells, inflammatory pathways (TNF-α/IL-6), Cyclin
1) Subcutaneous Injection (Recommended, Highly Effective)
Standard: 5–10mg/day, 5 days/week, 20 days as one course of treatment; stop for 2 weeks, 2–3 courses per year
Intensive (BPH/Chronic Prostatitis): 10–20mg/day, 10 days; maintenance afterwards 5mg/day
2) Oral enteric-coated capsules (convenient)
Standard: 10mg/day, on an empty stomach in the morning, 30 days as one course of treatment
3) Sublingual administration (adjunctive)
5mg/day, divided into 2 doses, taken on an empty stomach, 12 weeks
Strong prostate targeting: Specifically targets prostate tissue, does not affect other organs
Dual anti-inflammatory + anti-proliferative effects: Relieves prostatitis pain, reduces prostate enlargement volume, improves urination
No hormone side effects: Does not interfere with testosterone/PSA, safe for long-term use, no impact on sexual function
Epithelial repair + anti-aging: Restores prostate youthfulness, reduces cell aging, reduces inflammation recurrence
Good tolerability: No serious adverse reactions, suitable for long-term health maintenance in middle-aged and elderly people
Limited human evidence: No large-sample double-blind treatment, efficacy depends on animal + small-sample clinical + user experience
Slow onset of action: Effective in 2–4 weeks, not suitable for emergency treatment of acute inflammation
Relatively high price: Injection (20mg) $60–$90/bottle; oral monthly fee $50–$80
Individual Differences: Approximately 5–8% of users reported mild urinary frequency and abdominal distension initially (relieved within 1 week).
Regulatory Gaps: Not a pharmaceutical product; market purity/counterfeit risks exist; GMP-certified manufacturers must be selected.
Benign Prostatic Hyperplasia (BPH): Frequent urination, nocturia, weak urine stream, difficulty urinating
Chronic Nonbacterial Prostatitis: Pelvic pain, perineal distension, incomplete urination, recurrent inflammation
Prostate Health for Middle-Aged and Elderly Individuals: 45+ - Prevents hyperplasia, delays aging, maintains urinary health
Male Reproductive Health: Improves prostate function, helps improve sperm quality
Post-operative Repair: After minimally invasive prostate surgery, reduces edema and inflammation, accelerates recovery
BPH (56 years old): Injection 10mg/day × 20 days, nocturia reduced from 5 times to 1 time, significantly improved urine flow, IPSS decreased by 35%
Chronic Prostatitis (42 years old): Oral administration 10mg/day × 30 days Within days, perineal distension disappeared, urinary incontinence was relieved, and recurrence decreased.
Middle-aged and elderly health care (62 years old): Two courses of injections per year, stable prostate volume, no hyperplasia progression, and normal urination.
(I) Dietary Recommendations
✅ Recommended: Tomatoes (lycopene), pumpkin seeds, green tea, nuts, deep-sea fish (Omega-3), zinc/selenium, to support prostate health and reduce inflammation.
❌ Avoid: High-salt, spicy, alcoholic, caffeine, red meat, and fried foods, which can aggravate prostate congestion and inflammation.
(II) Drug Interactions
Can be used synergistically:
Testagen (testosterone peptide): Synergistic effect on the male reproductive system, improving sexual function.
Epithalon (pineal peptide): Anti-aging combination, improving overall condition.
Saw palmetto/ Lycopene: A natural prostate health supplement, enhancing effects. Use with caution in combination.
Alpha-receptor blockers (tamsulosin): Synergistically improve urination; blood pressure monitoring is required to prevent hypotension.
Nonsteroidal anti-inflammatory drugs (ibuprofen): Enhance anti-inflammatory effects; long-term use requires stomach protection.
Contraindications: Prostate cancer, severe liver or kidney dysfunction, allergies, pregnant/lactating women (not required for men).
Prostamax (KEDP): Prostate-targeted – anti-inflammatory, anti-proliferative, improves urination.
Livagen: Liver-targeted – repairs liver function, detoxifies, anti-liver aging.
Pancragen: Pancreas-targeted – balances blood sugar, repairs pancreatic islets, metabolic syndrome.
Testagen: Testicular/reproductive-targeted – increases testosterone, improves sexual function, sperm quality.
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