Application Scenarios
Cellular Energy Metabolism Research: As a key coenzyme in the mitochondrial electron transport chain, NAD+ directly participates in ATP production and is a fundamental tool molecule for studying cellular energy metabolism, mitochondrial function, and oxidative phosphorylation mechanisms.
Anti-aging and DNA Repair Research: NAD+ is an essential substrate for the Sirtuins longevity protein family (SIRT1, SIRT3, etc.) and PARP DNA repair enzymes, and is widely used in cutting-edge research on cellular aging mechanisms, telomere protection, genome stability, and oxidative stress damage repair.
Neuroprotective Research: Studies have shown that NAD+ can enhance mitochondrial health and improve cognitive function, making it an important tool in animal model studies of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.
Metabolic Regulation Research: NAD+ participates in the regulation of the AMPK signaling pathway, affecting insulin sensitivity, lipid metabolism, and inflammatory responses, and is an important auxiliary molecule for studying the mechanisms of metabolic syndrome, obesity, and type 2 diabetes.
Cosmetic Formulation Development: As an active ingredient in high-end skincare products, NAD+ supports collagen synthesis, improves skin elasticity, and reduces oxidative damage. It is commonly used in the formulation of anti-aging skincare products such as serums, creams, and masks, and is often used in synergy with hyaluronic acid, vitamins C/E, and peptides.
Usage Method
Reconstitution: It is recommended to slowly add NAD+ along the side of the vial using sterile water for injection, PBS buffer (pH 7.0-8.0), or Tris-HCl buffer (pH 7.5-8.5), and gently swirl to mix until dissolved. Vigorous shaking is strictly prohibited. NAD⁺ has good stability in neutral to slightly alkaline environments.
Concentration Preparation: Prepare working solutions according to experimental or formulation requirements. It is recommended to prepare and use immediately. If aliquoting is necessary, it is recommended to aliquot into single-use doses and freeze at -80°C or -20°C, avoiding repeated freeze-thaw cycles (no more than 3 times recommended).
pH Note: Avoid long-term storage or use under strongly acidic conditions (pH < 5). An acidic environment can cause NAD⁺ to hydrolyze into nicotinamide and ADP-ribose, resulting in loss of coenzyme activity.
Incompatibility: Avoid direct contact with strong reducing agents (which may reduce NAD⁺ to NADH), strong oxidizing agents, and heavy metal ions. Before mixing with other active ingredients, it is recommended to conduct small-scale compatibility verification to observe for precipitation or changes in UV absorption.
Operating Environment: Operate in a clean environment, wearing gloves and masks to prevent the introduction of reducing substances or microbial contamination.
Why Choose Us?
1. Direct Factory, Excellent Cost and Delivery Time: As a self-manufacturing direct factory, we independently complete the entire process from starting material synthesis, enzyme-catalyzed/chemical synthesis reactions, multi-step purification to final freeze-drying into powder. There are no middlemen adding to the price, ensuring a transparent pricing system. We also maintain gram-to-kilogram inventory to support a smooth transition from laboratory-scale trials to industrial-scale mass production, achieving true "factory-to-laboratory" direct supply.
2. Professional Synthesis and Purification Equipment, Mature Processes
Enzymatic/Chemical Synthesis Platform: Equipped with high-precision reactors and temperature control systems, optimizing the synthesis pathway of oxidized NAD⁺ to ensure the product is predominantly oxidized (NAD⁺), reducing NADH and other reduced impurities.
Preparative Purification System: Features multi-channel preparative HPLC and ion exchange chromatography systems for efficient removal of residual starting materials such as nicotinamide and adenine, as well as byproducts.
Precision Quality Control Center: Equipped with HPLC, UV-Vis (characteristic absorption peaks at approximately 259 nm and 340 nm for comparison), mass spectrometry (MS), and moisture analyzer for comprehensive characterization of purity, oxidation state ratio, and molecular weight.
Each batch comes with a Certificate of Analysis (COA), covering key indicators such as HPLC purity, UV characteristic spectra, moisture, heavy metals, and microbial limits.
3. Stable Supply and Ample Production Capacity
Established multi-batch rolling production plans and strategic raw material reserves, with regular specifications kept in stock, shortening the waiting period for R&D projects.
A mature standardized SOP and change control system allows for flexible capacity expansion based on market demand, ensuring continuous supply for large-scale orders.
Cooperation with professional logistics companies provides light-protected, sealed, and low-temperature transportation options to ensure product stability during delivery.
4. Stable Quality and Excellent Batch Consistency
Source Control: Starting materials such as nicotinamide and adenine are all high-purity pharmaceutical/reagent grade, with full inspection upon arrival at the factory.
Process Control (IPC): Intermediate control points such as pH, temperature, and oxidation state conversion rate are set during the reaction process, with real-time correction of deviations.
Stability Database: Accelerated and long-term stability testing procedures are established to ensure high consistency in purity, oxidation state ratio, solubility, and UV characteristic absorption across different batches, meeting the stringent requirements of scientific reproducibility and industrial production.
FAQ
Q: Where are you located?
A: Our products are from Shenzhen, China.
Q: What is the minimum order quantity?
A: The minimum order quantity is 10 bottles/set.
Q: How long does it take to ship? A: In-stock orders will be shipped within 24 hours.
Q: What purity level can you provide?
A: Standard purity 99%.
Q: Which courier service do you use?
A: FedEx, DHL, UPS, and postal services are available.
Q: How long does shipping take?
A: Approximately 10-15 days.
Q: Can you provide a COA (Certificate of Account) quality inspection report and HPLC (High-Performance Computing) report?
A: Yes, all goods undergo professional testing before shipment.
Q: Do you support OEM branding?
A: OEM branding is supported, subject to minimum order quantity requirements.
Q: What are your after-sales service terms?
A: After the customer receives the goods, if the quality problem is confirmed to be caused by our production, they can enjoy free replacement or refund. We adhere to a pragmatic and responsible service principle, actively responding to and properly handling all kinds of issues, without shirking responsibility or avoiding problems, and fully protecting customer rights.
Q: What payment methods are available?
A: We support bank transfer, Bitcoin, Transferwise, and Xoom.
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