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HGH 176/191 (fragment) peptide powder is used in lipid metabolism regulation and tumor targeted therapy research.

HGH 176/191 (fragment) peptide powder is used in lipid metabolism regulation and tumor targeted therapy research.

HGH 176-191 (Fragment), officially known as Human Growth Hormone Fragment 176-191, is a synthetic polypeptide fragment composed of amino acid sequences from the C-terminus of natural human growth hormone (hGH) at positions 176 to 191. This fragment retains the lipid metabolism regulatory activity of the hGH core while eliminating growth effects associated with the IGF-1 axis, making it a high-purity research-grade product in the field of bioactive peptide raw materials in recent years.

Product Introduction

Application Scenarios

1. Lipid Metabolism Regulation Research
HGH 176-191 is an ideal tool peptide for studying the regulatory mechanisms of lipid metabolism. Studies have shown that this fragment can effectively stimulate lipolysis and inhibit lipogenesis. Its mechanism of action mainly mimics the pathway of natural growth hormone in regulating lipid metabolism, but it does not produce the hyperglycemic or growth-promoting effects induced by natural growth hormone.

2. Tumor Targeted Therapy Research
Recent studies have found that HGH 176-191 has a high affinity binding capacity to various breast cancer-related protein targets (such as Ki-67, MiB protein, and estrogen receptor). Based on this characteristic, this peptide has been used to construct targeted drug delivery systems-loading it onto the surface of chitosan nanoparticles can enhance the accumulation and cytotoxicity of the chemotherapeutic drug doxorubicin in MCF-7 breast cancer cells, demonstrating its potential application as a tumor-targeted drug delivery carrier.

3. Drug Development and Bioactivity Evaluation
As a research tool for the functional domains of growth hormone, HGH 176-191 can be used to evaluate the effects of specific amino acid sequences on insulin sensitivity and glucose-lipid metabolism, providing structure-activity relationship (SAR) data support for the development of drugs for metabolic diseases.

 

 

Why Choose Us?

Direct Supply from the Source
We are a source-oriented manufacturing enterprise specializing in the research and production of peptide raw materials, integrating R&D, production, and sales, eliminating intermediate links. From amino acid raw materials to finished peptide powder, the entire process is independently controlled, providing customers with highly competitive source prices.

 

Professional Production Equipment
The company is equipped with internationally advanced continuous flow peptide synthesis systems and preparative high-performance liquid chromatography (Prep-HPLC) purification equipment. Continuous flow synthesis technology can precisely control reaction conditions, effectively reducing side reactions and the generation of missing sequences, ensuring high purity (up to 98% or more) and excellent batch-to-batch consistency.

 

Stable Supply and Ample Capacity
Relying on mature production processes and large-scale production lines, we have the capacity to supply in kilograms and above, meeting different order needs from small R&D packages to large-scale production. A mature supply chain management system ensures a continuous and stable product supply, unaffected by market fluctuations.

 

Stable Quality, Comprehensive Quality Control: From raw material warehousing and synthesis to finished product release, strict quality control is implemented throughout the entire process. Each batch of product is verified by HPLC, MS (mass spectrometry), and other testing methods to ensure sequence correctness, purity, and proper disulfide bond pairing. We are committed to providing customers with high-end peptide raw materials with consistent quality and clear impurity profiles.

 

 

Dissolution and Usage Recommendations:
Solvent Selection: HGH 176-191 is in lyophilized powder form and can be directly dissolved using sterile deionized water or PBS buffer (pH 7.4). For preparing high-concentration stock solutions, DMSO can be used as a dissolution aid, followed by dilution with buffer to the working concentration.

Allowing Aliquoting and Freezing: After dissolution, it is recommended to aliquot into single-use quantities to avoid repeated freeze-thaw cycles that could lead to peptide degradation or activity loss.

Pre-use Treatment: After removing from the freezer, allow to equilibrate at room temperature for 15-30 minutes before opening to prevent condensation from affecting weighing accuracy.

 

 

FAQ:

Where is your product manufactured?

A: Our products are from Shenzhen, China.

Q: What is the minimum order quantity?

A: The minimum order quantity is 10 bottles/set.

Q: How long does it take to ship?

A: In-stock orders will be shipped within 24 hours.

Q: What purity level can you provide?

A: Standard purity 99%.

Q: Which courier service do you use?

A: FedEx, DHL, UPS, and postal services are available.

Q: How long does shipping take?

A: Approximately 10-15 days.

Q: Can you provide a COA (Certificate of Authorization) quality inspection report and HPLC (High-Performance Computing) report?

A: Yes, all goods undergo professional testing before shipment.

Q: Do you support OEM/ODM?

A: OEM/ODM service is supported, subject to the minimum order quantity requirement.

Q: What are the after-sales service procedures?

A: After the customer signs for the goods, if it is confirmed that the quality problem is caused by our production, they can enjoy free replacement or refund. We uphold a pragmatic and responsible service principle, actively responding to and properly handling all kinds of issues, without shirking responsibility or avoiding problems, and making every effort to protect the rights and interests of our clients.

Q: What payment methods are available?

A: We support bank transfers, Bitcoin, Transferwise, and Xoom.

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