When I first heard the name Livagen (Lys-Glu-Asp-Ala), I thought it was some new skincare product. After some research, I discovered it's actually a short peptide closely related to Epitalon.
What I find most amazing is its ability to "awaken" genes that have become "lazy" due to aging at the cellular level. Especially effective for the immune system, gastrointestinal tract, and liver, it can reactivate dormant genes, such as ribosomal genes that promote protein production. Simply put, it acts like a "veteran employee" within the cell, helping to restart the machines within the body that have stopped functioning due to age, combating aging from the inside out.
Core Advantages and Functions (Based on Preclinical/In Vitro Studies)
Chromatin Depolymerization: In experiments with aging lymphocytes and hepatocytes, it can induce heterochromatin depolymerization, reactivating ribosomal genes that have been "locked up" due to age, restoring their ability to synthesize proteins. This is quite valuable in anti-aging research.
Hepatoprotective Potential: In animal models (hepatitis, liver fibrosis), it has been observed to regulate antioxidant activity, aid repair, and maintain the expression of genes related to liver metabolism and detoxification, making it a key area of observation in liver bioregulation.
Enzyme Inhibitory Activity: It can inhibit enkephalinase degradation enzymes in human serum (IC50 approximately 20 µM) without directly binding to opioid receptors. Theoretically, this could extend the duration of endogenous analgesic signals, but this area is still in the in vitro stage.
Structural Stability and Good Absorption: The short peptide chain combined with high stability (purity ≥98% according to standard) makes it less prone to degradation in cell experiments. Its small molecular size also allows for easy permeation, making it a convenient research reagent.
Storage Conditions
Lyophilized Powder (before dilution): Must be stored at -20 °C or lower, protected from light and dry. Moisture prevention is crucial. Unopened, it can generally last for 24 months. For short-term handling, it can be stored at 2–8 °C for several months, but avoid moisture.
After reconstitution (after dilution with water): It is recommended to aliquot and store at -20 °C or 2–8 °C. Crucially, avoid repeated freeze-thaw cycles, as this can cause peptide chain collapse. Use the reconstituted product as soon as possible; refrigerate for no more than 2–4 weeks. Discard immediately if turbidity or discoloration is observed.
Handling Details: Weigh in a dry environment. Use sterile water or buffer solution for reconstitution. Gently shake, do not vigorous shaking. Allow the tube to return to room temperature before opening to prevent condensation from damaging the sample.
## Precautions
1. For compliant laboratory cell and animal research use only. There is no complete long-term human safety clinical data. Personal oral administration or self-injection is strictly prohibited.
2. Wear gloves and goggles when handling the powder. The powder is easily dusty; avoid inhalation or contact with eyes, nose, or skin. If contact occurs, immediately rinse with plenty of running water.
3. Only use neutral sterile pure water or PBS buffer for dissolution. Strong acids and alkalis will directly destroy the peptide structure and completely eliminate its hepatocyte repair activity.
4. Use with caution in experimental models of liver tumors and abnormal hepatocyte proliferation, as this product can regulate hepatocyte proliferation genes and interfere with tumor monitoring indicators.
5. Perform sterile operation throughout the solution preparation process. Open the cap as quickly as possible each time to minimize powder exposure to air and oxidation.
6. All experimental waste liquids and remaining dry powder must be disposed of as hazardous biochemical waste. Do not dispose of them directly down the drain.
7. Store in a lockable drying cabinet, away from children and pets to prevent accidental ingestion.
How to Order?
First, please inform us of your needs or application scenario.
Second, we will provide a quotation based on your needs or our suggestions.
Third, the customer confirms the sample and pays a deposit.
Fourth, we will arrange production. Discounts are available for bulk orders.
How is the quality of your products? First, our products are of excellent and stable quality. We conduct 100% testing before shipment.
Therefore, we conduct strict quality control before shipment. If any quality problems are found to be caused by us, we will replace the product free of charge or provide a refund. How to build a long-term, positive partnership with us?
1. We insist on providing high-quality products and competitive prices to ensure customer benefits;
2. We respect every customer, treat them as friends, and sincerely do business and make friends with them, no matter where they come from.
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