ARA-290, also known as cinbinetide, is a synthetic 11-amino acid peptide derived from the B-helix functional region of erythropoietin (EPO). Through molecular modification, the hematopoietic-related activity of EPO is eliminated while retaining its tissue repair capabilities. It is a highly regarded research tool in studies of nerve injury and inflammation mechanisms. Based on years of experience working with laboratories, many researchers choose it primarily to avoid the hematopoietic-related variables associated with full-length EPO, resulting in fewer experimental interferences.
Core Function and Physical Mechanism:
Ara-290 (cinbinetide) is a synthetic peptide composed of 11 amino acids whose three-dimensional structure precisely mimics the B-helix region of erythropoietin (EPO). At the physical and molecular level, it acts as a specific agonist of the innate repair receptor (IRR, i.e., the EPO/CD131 heterologous receptor), precisely targeting and activating this receptor. This selective activation not only completely avoids the erythropoiesis-promoting side effects caused by traditional EPO binding to homodimer receptors, but also effectively antagonizes the production of pro-inflammatory molecules (such as TNF), initiating endogenous tissue protection, anti-inflammatory, and nerve repair processes.
Applicable Scenarios:
Currently, the focus is mainly on clinical intervention research in type 2 diabetes and its complications (such as diabetic painful neuropathy and diabetic macular edema). In addition, it has shown great application potential in research on sarcoidosis-related neuropathy, multiple sclerosis (EAE model), and the repair of ischemic tissue damage.
Storage Conditions:
First, freeze the dry powder at -20℃. It can last for two to three years. Alternatively, refrigerate at 2–8℃ (but not more than two years). Keep away from light and moisture.
After mixing with water, it becomes more delicate: refrigerate at 2–8℃ and use within 28 days. Do not freeze the liquid-freezing even once will cause ice crystals to tear the peptide chains, reducing activity by at least 20-30%, and it cannot be recovered after thawing.
For reconstitution, use antibacterial water, slowly pushing along the bottle wall and gently rolling; avoid vigorous shaking. Slight residue on the bottle walls after mixing is normal, but if it becomes cloudy, contains particles, or changes color, discard it immediately. Even if it looks clear, it may have already lost its active ingredient. Don't hesitate to discard expired bottles.
Do not store it on the refrigerator door shelf, as temperature fluctuations are extremely damaging. When taking it out, let it sit at room temperature for a few minutes before opening the lid to prevent condensation from entering the bottle.
Precautions:
For research use only. Absolutely do not touch people: Currently, this is a purely research reagent and must never be used for human or animal clinical treatment! Don't be curious just because it looks like medicine; we absolutely will not use it for experiments on ourselves.
Be gentle when dissolving: Avoid violent shaking when preparing the solution. It's best to adjust the pH to around 8 with ammonia, or use 0.1M NaOH to dissolve it. It's actually quite soluble in water (50 mg/mL), but handle it gently.
Full protection is essential: Gloves, masks, and goggles are all necessary during operation. If you accidentally get it on your skin or in your eyes, don't hesitate to rinse it with plenty of water. Your health is the foundation of our scientific research, so don't be careless!
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