Bronchogen is a organ-targeting bioregulatory tetrapeptide from the Havencin series, with the sequence Ala-Glu-Asp-Leu. It specifically targets airway and bronchial epithelial tissue. Currently available only as a lyophilized research powder, it is used year-round in cell and animal experiments related to chronic bronchitis, COPD, lung aging, and airway mucosal damage. Unlike ordinary anti-inflammatory peptides that only act on cell membrane receptors, this small molecule can penetrate the cell nucleus to directly regulate lung epithelial-related genes, repairing damaged airway barriers. It is a representative peptide in lung-specific research and is often combined with other organ regulatory peptides in comprehensive organ anti-aging control experiments.
Core Advantages and Functions:
Lung/Bronchi Targeting: Selectively acts on bronchial epithelial cells, promoting mucociliary clearance, supporting the synthesis of surfactant in type II alveolar cells, and maintaining airway epithelial integrity.
Anti-inflammatory & Tissue Repair: In animal models of COPD, chronic bronchitis, and pulmonary fibrosis, it shows the ability to downregulate inflammatory factors, reduce airway remodeling, and assist in lung tissue repair.
DNA Stabilization & Gene Regulation: Short peptides can enter the nucleus and bind to DNA/CTG motifs, enhancing DNA thermal stability and reactivating the transcriptional program of aging cells-this is the source of its "anti-aging/reactivation" claim.
Local Immune Support: Can promote respiratory secretory IgA, enhancing local mucosal defense.
Storage Conditions
Lyophilized Powder (Undissolved)
-20℃ Long-term (1-2 years), short-term 2-8℃, protected from light and dry for ≤6 months
Reconstituted Solution
Recommended -20℃ aliquoting and freezing; short-term refrigeration 2-8℃ for ≤1-2 weeks
Oral Capsules (Russian Version)
+2~+25℃, dry and protected from light
Precautions & Contraindications
Research/Non-Pharmaceutical Use: Lyophilized powder is for laboratory research only; the oral version is registered in Russia as a biological regulator/dietary supplement and should not be used as a prescription drug to treat asthma/COPD or as a substitute for regular inhalers.
**Cancer Concerns:** Theoretically, it can inhibit apoptosis and affect p53-not recommended for active lung cancer, lung metastases, or patients undergoing radiotherapy or chemotherapy.
**Autoimmune Diseases:** It has immunomodulatory effects; careful evaluation is advised for active autoimmune lung diseases (such as lung involvement in systemic lupus erythematosus).
**Allergies:** Very few people are allergic to short peptides; discontinue use immediately if rash/itch occurs.
**Contraindications:** No safety data available for pregnant women, breastfeeding mothers, and children under 18 years of age; contraindicated for those intolerant to peptide components.
**Side Effects:** Injectable versions may cause local redness/swelling/pain; oral versions may occasionally cause mild nausea (on an empty stomach), which usually resolves spontaneously and is short-lived.
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