Follistatin 344, abbreviated as FST-344, is a full-length recombinant follicle-stabilizing protein composed of 344 amino acids, belonging to the TGF-β superfamily of binding proteins. We provide high-purity lyophilized powder, with a standard specification of 1mg/vial. It is a white, loose powder, free of impurities and odors, with good water solubility, and becomes clear and transparent after dissolution.
It is currently the most stable and commonly used full-length isomer in research and application. In vivo, it is metabolized into FS-315 (circulating form) and FS-288 (tissue-bound form), but exogenous use of 344 directly yields the most stable and controllable effects.
Follistatin was first discovered in follicular fluid in the 1980s, initially known only to inhibit follicle-stimulating hormone (FSH). Later research gradually confirmed that it can strongly bind to and neutralize myostatin (GDF-8).
Its real breakthrough came from **animal experiments showing myostatin deficiency**: cattle and mice born with insufficient myostatin had 2-3 times more muscle mass than normal individuals, with lower fat and greater strength. Follistatin 344 is a "blocker" of natural myostatin, essentially "releasing the brakes" on muscle growth.
Subsequent gene therapy and peptide research have focused on it, and FST-344 is now a core tool peptide in research on muscle growth, anti-muscle loss, and age-related sarcopenia.
Name: Follistatin 344 (FST-344, FS-344)
Purity: ≥98% (HPLC, MS dual detection)
Appearance: White lyophilized powder
Molecular Weight: Approx. 37–38 kDa
Specification: 1 mg/bottle (customizable)
Solubility: Easily soluble in sterile water and antibacterial water
Shelf Life: Unopened 2 years; After dissolution, refrigerate for 7 days, freeze for 30 days
Source: Recombinant expression (E. coli or eukaryotic expression), free of animal-derived impurities
Unopened (lyophilized): Store at -20℃ protected from light, shelf life 2 years, avoid repeated thawing.
After dissolution: Refrigerate at 2–8℃ for ≤7 days; freeze at -20℃ for ≤30 days. It is recommended to aliquot into single-use doses to reduce contamination.
Transportation: Cold chain with ice packs throughout. Place immediately in the refrigerator upon receipt; do not leave at room temperature for extended periods.
**Powerful Myostatin Blocker:** Myostatin acts as the body's natural "muscle brake," limiting muscle growth. FST-344 neutralizes it, preventing suppressed muscle growth and resulting in faster and more defined muscle mass after training.
**Activates Muscle Stem Cells and Accelerates Repair:** Enhances satellite cell activity, leading to faster recovery and reduced soreness after training, suitable for high-intensity training or muscle damage repair research.
**Promotes Muscle Protein Synthesis and Reduces Breakdown:** Makes muscles easier to build and less prone to loss, valuable for age-related sarcopenia and post-operative muscle loss.
**Mildly Improves Body Composition and Enhances Insulin Sensitivity:** Long-term use tends to promote muscle gain and fat loss, resulting in more defined muscle lines, while also contributing to metabolic health.
**Anti-fibrosis and Tissue Repair Support:** Studies show inhibitory effects on liver, lung, and skin fibrosis, a common tool in regenerative medicine.
**Full-length 344 amino acids:** Highest stability and activity, offering more comprehensive and stable effects than FS-315 and FS-288.
Purity ≥98%, excellent batch-to-batch consistency, each batch comes with a Certificate of Authorisation (COA), research/clinical grade quality.
Broad pathways of action: Not only blocks myosin, but also inhibits Activin A, providing multiple benefits including muscle building, anti-inflammation, and anti-fibrosis.
No serious acute side effects, good tolerability, suitable for long-term, low-cycle use.
Lyophilized packaging, easy to store, transport, and dissolve, providing peace of mind for customers.
Not a "laid-back muscle-building" treatment: Must be combined with strength training and a high-protein diet, otherwise the effect will be limited.
Affects reproductive hormones: May inhibit FSH, contraindicated during preconception, pregnancy, and breastfeeding.
Long-term high doses may affect blood lipids: A small number of people may experience a slight increase in LDL; cyclical use and regular monitoring are recommended.
Limited long-term human data: Peptide injections are mostly used in research/fitness circles, not as a legitimate drug, and should only be used in research or compliant settings.
Easily inactivated and contaminated after dissolution: Must be handled under aseptic conditions and used as soon as possible.
Research Laboratories: Research on muscle physiology, sarcopenia, fibrosis, and metabolic diseases.
Fitness/Performance Enhancement: Strength athletes, bodybuilders, and resistance trainers; muscle gain, improved recovery, and increased strength.
Anti-aging/Health Management: Prevention of sarcopenia in middle-aged and elderly individuals; postoperative muscle recovery; intervention for muscle loss due to prolonged bed rest.
Regenerative Medicine/Tissue Engineering: Research related to muscle repair, skin repair, and anti-fibrosis.
For research or compliant applications only. No commitment is made for human use.
Cyclical Use: The usual dosage is 100–200 mcg/day, subcutaneous injection, for 10–30 days as one cycle, with a 2–3 month rest period before resuming use.
Dissolution Must Be Aseptic: Use antibacterial water (BW) or sterile water for injection; do not use ordinary water.
Use with caution in individuals with allergies, liver or kidney disease, or hormone-related disorders.
Avoid combining with other myosin inhibitors to prevent the risks of excessive inhibition.
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