Chonluten is an organ-specific short peptide targeting the respiratory tract and lung epithelium. It is only available as a lyophilized research powder and is primarily used in experiments on lung aging, chronic bronchitis, airway mucosal damage, smoking-induced lung injury, and COPD-related cell and animal studies. It can penetrate lung cell nuclei to regulate epithelial repair genes, not only suppressing inflammation but also repairing damaged airway barriers. It is often used in combination with organ peptides such as Cartalax and Livagen for multi-organ aging controls and is frequently used in basic respiratory experiments.
## Core Functions
1. Repairs damaged bronchial and alveolar epithelial cells, reduces cell apoptosis caused by inflammation, toxins, and aging, restores the normal movement of airway cilia, and improves sputum production and secretion accumulation.
2. Inhibits the NF-κB inflammatory pathway in the lungs, significantly reduces the release of pro-inflammatory factors such as TNF-α and IL-6, alleviates airway congestion and edema, and reduces long-term chronic inflammatory damage to the lungs.
3. Promotes the synthesis of alveolar surfactant, maintains alveolar elasticity, improves pulmonary gas exchange function, and alleviates age-related oxygen deficiency and decreased exercise tolerance.
4. Inhibits excessive proliferation of pulmonary fibroblasts, reduces abnormal collagen accumulation, slows the progression of pulmonary fibrosis, and prevents post-traumatic pulmonary sclerosis.
5. Enhances the antioxidant level of lung tissue, scavenges respiratory free radicals, reduces continuous oxidative damage to the lungs from external stimuli, and slows down degenerative aging of lung tissue.
## Core Advantages
1. Highly targeted to the respiratory tract, regulating only lung and bronchial gene pathways with minimal interference to organs such as the heart, liver, and pancreas. Experimental indicators are clean, with no extraneous data fluctuations.
2. Integrated repair and anti-inflammation; no need to separately combine anti-inflammatory and mucosal repair reagents. A single component can complete the full set of airway damage indicators, simplifying experimental procedures and saving consumables.
3. The small-molecule tripeptide has good water solubility and can be directly dissolved in neutral sterile PBS or pure water without the need for special solubilizers. It is simple and convenient to prepare cell culture media and animal injection working solutions.
4. Unlike ordinary topical anti-inflammatory reagents, it can improve organic aging-related lung damage at the gene level, making its experimental conclusions more convincing for senile lung decline and long-term irritation-induced lung injury.
5. Animals show high tolerance to long-term administration with almost no organ stress or toxic reactions. Mature literature provides dosage references for COPD and aging-related lung injury models, and repeatable experimental results are stable.
## Storage Conditions
Keep the lyophilized powder tightly capped and store in a cool, dry place away from light and moisture. For long-term storage, aliquot into individual sealed tubes and store at -20°C in the dark. Repeated freeze-thaw cycles are strictly prohibited. Repeated thawing will hydrolyze the peptide chains, silently reducing lung repair activity. This effect is not visible to the naked eye but significantly deteriorates experimental results.
Prepared sterile working solutions should be refrigerated at 2–8℃ and used within 7 days. Prolonged storage can lead to oxidation, bacterial growth, and the solution becoming cloudy or discolored; discard immediately.
Keep away from windowsills, heated instruments, and humid reagent cabinets. Store separately, labeled, and categorized. Do not mix with strong acids or strong oxidizing reagents. Maintain a cold chain throughout transportation; prolonged exposure to room temperature will irreversibly reduce activity.
## Precautions
1. For compliant laboratory cell and animal research use only. There is no complete long-term human safety clinical data. Personal oral administration and self-injection are strictly prohibited.
2. Wear gloves and goggles when handling the powder. The powder is easily dusty; avoid inhalation or contact with eyes, nose, and skin. In case of accidental contact, immediately rinse thoroughly with plenty of running water.
3. Can only be dissolved in a pH-neutral sterile buffer solution. Strong acid or alkaline environments will directly destroy the peptide molecular structure, completely eliminating its airway repair and anti-inflammatory activities.
4. Use with caution in experimental models of lung tumors and abnormal epithelial cell proliferation, as this product can regulate cell proliferation genes and interfere with tumor-related monitoring indicators.
5. Perform aseptic procedures throughout the solution preparation process. Open the cap as quickly as possible each time to minimize prolonged exposure of the powder to air and prevent oxidation.
6. All experimental waste liquids and remaining dry powder must be disposed of as hazardous biochemical waste. Do not dispose of them directly down the drain.
7. Store in a lockable, dry storage cabinet, away from children and pets to prevent accidental ingestion.
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