Dermorphin is a polypeptide extracted from the skin of the South American tree frog. It has a very strong affinity for μ-opioid receptors, and its analgesic effect is far superior to morphine.
Its molecular structure contains D-type amino acids, making it difficult for enzymes in the body to break down, resulting in a long-lasting effect. Currently, it is only used in laboratory pharmacological research and has not been approved for medical formulation.
It is a controlled opioid-related peptide, which carries risks of addiction and respiratory depression. Its illegal use in competitive settings such as horse racing is prohibited, and its private injection into humans is forbidden.
Core Functions:
Potent Central Analgesia: High affinity for μ-opioid receptors → Inhibition of adenylate cyclase, closure of calcium channels, opening of potassium channels → Hyperpolarization of pain neurons, blocking ascending pain transmission in the dorsal horn of the spinal cord and the aqueduct of the midbrain, producing potent antinociception.
Opioid Receptor Research Tool: As a classic pure μ-selective ligand, it is used for MOR radioligand binding, analgesic efficacy verification, and research on opioid tolerance/addiction mechanisms.
Key Advantages:
Low Tolerance and Addiction Risk: Despite its potent effect, it carries a significantly lower risk of developing drug tolerance and physical dependence (addiction) compared to traditional morphine-like drugs.
Extremely Strong Resistance to Enzymatic Degradation: Because it contains a specific D-alanine (D-Ala), it is difficult for enzymes in the human body to degrade, resulting in a very long duration of action in the body.
Extremely High Receptor Selectivity: It has extremely high affinity for μ-opioid receptors and very low affinity for δ and κ receptors, making it an ideal natural probe for studying opioid receptor mechanisms.
Dermorphin is a polypeptide substance that is highly susceptible to degradation and inactivation if not stored properly. Specific conditions are as follows:
Storage Conditions:
Powder State (Long-Term): Must be sealed, protected from light, and stored in a frozen environment at -20°C or -80°C. Under these conditions, it can typically be stably stored for 1 to 3 years.
Solution State (Short-Term): Once dissolved, it is highly susceptible to degradation. It is recommended to aliquot into single-use small doses. It can be stored for approximately 6 months at -80℃ and only approximately 1 month at -20℃.
Absolute Contraindications: Strictly avoid repeated freeze-thaw cycles (usually no more than 3 times), and avoid high temperatures (>25℃) and strong light exposure.
Precautions for Use: This product is a potent opioid peptide with strong addictive properties. Overdose can suppress respiration. It must never be taken orally or injected into humans.
Wear gloves and goggles during handling. Avoid direct skin contact and inhalation of the powder. If it comes into contact with skin, rinse immediately with water.
For use only in legitimate laboratory pharmacological research. It is prohibited for use on racing animals such as racehorses. Unauthorized use and distribution are illegal.
Use sterile buffer solution for dissolution, avoiding strong acid or alkaline environments. The diluted solution should not be stored for extended periods.
Dispose of experimental waste liquid and residual powder as controlled chemicals. Do not discard or dump them arbitrarily.
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