Product Introduction:
DSIP (δ-sleep-inducing peptide) is a long-established neuropeptide that remains highly valuable for research. Since its discovery in the 1970s, it has played a crucial role in neuroscience, peptide drug development, and biological regulation research. DSIP is a short peptide composed of only 9 amino acids, initially attracting attention due to its potential relationship with sleep regulation; however, modern research has expanded its scope of action to include stress regulation, nervous system physiological responses, and various homeostasis-related mechanisms.
Part 1: Basic Concepts and Structural Composition of DSIP
DSIP is a naturally occurring neuroregulatory peptide found in mammals. Its amino acid sequence is as follows:
Trp–Ala–Gly–Gly–Asp–Ala–Ser–Gly–Glu
The characteristics of this sequence are:
It consists of 9 amino acids, classifying it as a short peptide.
It is rich in glycine (Gly), exhibiting high structural flexibility.
It contains both acidic amino acids (Asp, Glu) and hydrophobic amino acids (Trp, Ala), resulting in unique folding properties.
It is a hydrophilic peptide with good water solubility. These structural features give DSIP good solubility in water and polar solvents and may play a regulatory role in various physiological processes.
Part Two: Classification of High-Quality DSIP Peptides
Based on different applications and production standards, DSIP raw material powders can be classified into the following categories:
I. Pharmaceutical Grade
Characteristics: Extremely high purity (typically ≥99%), with strict control over indicators such as metal impurities, residual solvents, and microbial limits.
Applications: Scientific research, high-end experiments, drug development, GLP/GMP experimental systems.
Its preparation typically employs solid-phase peptide synthesis (SPPS) and is purified to extremely high standards by high-performance liquid chromatography (HPLC).
II. Research Grade
Purity is typically between 95% and 98%, suitable for: cell experiments, raw material validation, and early scientific exploration.
Compared to pharmaceutical grade, impurity control requirements are slightly lower, but rigorous testing of the accuracy of the amino acid sequence and the purity of the major peaks is still necessary.
III. Industrial Grade or Custom Grade
Different modification methods can be used depending on experimental needs, including: N-terminal protection, C-terminal amidation, sequence extension, fluorescent labeling, PEG modification, etc.
This type is suitable for special model studies, target binding experiments, etc.
Part Three: Detailed Explanation of Physicochemical Properties
DSIP has several advantages in physical and chemical properties, making it particularly suitable as a research-grade peptide raw material.
1. Appearance and Color
Typical appearance of high-quality DSIP raw material powder:
Color: White to off-white
State: Loose powder or fine powder solid
Touch: Dry, non-clumping, good flowability
Impurities: No visible impurities, no discoloration
Obvious yellowing or browning usually indicates oxidation or improper storage.
2. Solubility
DSIP is a hydrophilic short peptide with excellent solubility:
Very soluble in water
Soluble in dilute acetic acid or buffer solutions
Also shows good solubility in DMSO
Depending on experimental requirements, a solution with a pH of 6-7 is recommended to maintain structural stability.
3. Molecular Properties
Molecular Formula: C₃₅H₄₈N₁₀O₁₅
Molecular Weight: Approximately 849.8 Da
Isoelectric Point (pI): Approximately 5.0–6.0
Structural Morphology: Random coil structure, highly flexible
The amino acid composition gives it good diffusion and solubility in physiological environments.
4. Stability
DSIP is less stable than some cyclic peptides, mainly because:
It is easily decomposed in solution
It is sensitive to light, temperature, and oxidation
Lyophilized powder form offers the best stability.
Therefore, high-quality DSIP powder is almost always supplied in lyophilized powder form.
Part Four: Advantages of High-Quality DSIP Raw Materials
1. High Purity, Low Impurities
High-quality DSIP is synthesized using solid-phase synthesis technology and repeatedly purified by HPLC to ensure accurate sequences, low metal impurities, and few abnormal peaks.
2. Stable Lyophilization Process
The lyophilized powder form effectively protects the peptide structure:
Prevents oxidation
Extends shelf life
Facilitates transportation and long-term storage
3. Excellent Solubility
Its strong hydrophilicity makes it very easy to dissolve and suitable for preparation in biological experiments.
4. Small Molecular Weight, Simple Structure
The 9-peptide structure offers several advantages:
Rapid diffusion
Easy absorption
Easy modification (N-terminus, C-terminus, sequence)
5. High Scalability
DSIP can be easily modified in the following ways:
Amideation enhances stability
Cyclization enhances resistance to degradation
PEG modification can extend the blood half-life
Fluorescent labeling is used for tracking studies
This gives it great potential in modern peptide drug research.
Our Advantages
1. Quality: Every product undergoes rigorous testing by our professionals and is ISO certified.
2. Price: As a factory, our prices are significantly lower than our competitors. Discounts are available for bulk orders.
3. Shipping: We have ample stock and can ship within 24 hours of payment.
4. Comprehensive reshipment policy to maximize customer benefits and minimize potential losses.
5. Excellent after-sales service: We track your package throughout the entire process until delivery and make every effort to resolve any issues you encounter.
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