Methods of Application
Route: Primarily intramuscular injection (IM), but can also be used for intradermal injection (hyperhidrosis), subcutaneous injection (partial analgesia), or intravesical injection (neurogenic bladder).
Reconstitution (Critical Step):
Reconstitute with 0.9% sterile saline for injection. Do not use other solvents.
Common Reconstitution Concentration: 1 mL for 100 U (standard), or 2 mL for 100 U (2-fold dilution, slightly larger diffusion radius, for large muscle groups or cosmetic applications).
Procedure: Slowly inject along the bottle wall, gently swirling without shaking to avoid air bubbles and protein denaturation. The reconstituted liquid should be colorless and transparent; discard if cloudy.
Dosage Principles:
Precise Dosage: Titrate according to muscle volume, degree of cramping, and previous reactions; err on the side of under-dosing.
Safety Upper Limit: The total dose for adults is usually ≤400 U; the interval between two injections should be ≥3 months to prevent the development of neutralizing antibodies (immune resistance).
Injection Techniques: Anatomical localization (surface landmarks/electromyography/ultrasound guidance) + multi-point micro-injection. Cosmetic injections require strict control of the diffusion range to avoid affecting adjacent muscles (e.g., ptosis due to levator palpebrae superioris muscle involvement).
Application Scenarios
Core Approved Indications (FDA/NMPA):
Neuromuscular Spasms: Blepharospasm, hemifacial spasm, spasmodic torticollis, upper limb spasticity after stroke, lower limb spasticity in children with cerebral palsy.
Autonomic Nervous System/Glands: Severe primary hyperhidrosis of the armpit/palms/plantar plexus, neurogenic overactive bladder.
Pain: Chronic migraine (preventative), adjunctive treatment for trigeminal neuralgia.
Cosmetic (Medical Aesthetics): Frown lines (brow lines), crow's feet, forehead wrinkles, masseter muscle hypertrophy (face slimming), calf muscle hypertrophy.
Off-label applications:
Dermatology: Androgenetic alopecia (scalp injection), keloids/hypertrophic scars, postherpetic neuralgia, rosacea erythema.
Gastroenterology: Achalasia, anal fissures, Oddi sphincter dysfunction.
Urology: Interstitial cystitis/bladder pain syndrome.
Oral and maxillofacial: Temporomandibular joint disorder (TMD), bruxism.
Storage conditions:
Unreconstituted lyophilized powder: Store in original packaging, protected from light, at 2–8°C (do not freeze). Stability under these conditions is up to 36 months (refer to the package insert for specific details).
Reconstituted solution:
Theoretically, it can be stored at 2–8°C for 24 hours (some packages allow 4–6 hours).
Clinical practice recommendations: Given the decrease in toxin potency over time and with temperature fluctuations, it is strongly recommended to use immediately after reconstitution; discard any remaining solution. If temporary storage is necessary, strict refrigeration and time labeling are required, and the storage time should not exceed 24 hours.
Transportation: Cold chain throughout (2–8℃), avoid violent shaking and direct sunlight.
FAQ
Q: What is the minimum order quantity?
A: The minimum order quantity is 10 bottles/set.
Q: How long does it take to ship?
A: In-stock orders will be shipped within 24 hours.
Q: What purity can you provide?
A: Standard purity 99%.
Q: Which courier service do you use?
A: FedEx, DHL, UPS, and postal services are available.
Q: How long does shipping take?
A: Approximately 10-15 days.
Q: Can you provide a COA quality inspection report and HPLC liquid chromatography test report?
A: Yes, all goods undergo professional testing before shipment.
Q: Do you support OEM labeling?
A: OEM labeling service is supported, subject to the minimum order quantity requirement.
Q: What is the after-sales service like? A: After the customer signs for the goods, if the quality problem is confirmed to be caused by our production, they can enjoy free replacement or refund. We adhere to the service principle of pragmatism and responsibility, actively respond to and properly handle all kinds of issues, without shirking responsibility or avoiding problems, and do our best to protect the rights and interests of our customers.
Q: What payment methods are available?
A: We support bank transfer, Bitcoin, Transferwise, and Xoom.
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