How much does CJC-1295 (DAC-free) increase growth hormone?
Clinical data show that CJC-1295 can increase growth hormone (GH) levels 2-10 times and insulin-like growth factor-1 (IGF-1) levels 1.5-3 times compared to baseline. However, these data come from studies of the extended-release CJC-1295 (DAC version).
Key differences of the DAC-free version (Mod GRF 1-29):
Shorter half-life: Approximately 30 minutes, requiring more frequent dosing (1-3 times daily) compared to the DAC version (1-2 times weekly).
Natural pulsatile: Its short duration preserves the body's natural, intermittent (pulsatile) growth hormone release pattern, which is associated with a lower risk of receptor desensitization.