5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetically produced, small-molecule, selective, non-peptide inhibitor of NNMT (nicotinamide N-methyltransferase). By blocking NNMT, which depletes nicotinamide and SAM (S-adenosylmethionine), it increases intracellular NAD⁺ levels and the methyl donor pool. In animal models, it has shown effects such as promoting lipid oxidation, reducing white adipose tissue accumulation, improving insulin sensitivity, and potential muscle regeneration.
Core Advantages and Functions:
Targeted Inhibition of NNMT and Enhancement of NAD⁺: With age or obesity, NNMT enzyme activity increases, leading to significant depletion of intracellular nicotinamide and a decrease in NAD⁺ levels. 5-Amino-1MQ precisely blocks NNMT, reducing NAD⁺ loss and thus increasing intracellular NAD⁺ reserves, providing sufficient energy for mitochondria.
Promoting Fat Burning and Improving Metabolism: By inhibiting NNMT, it effectively reduces the size of adipocytes, decreases the accumulation of white adipose tissue, and simultaneously enhances glucose uptake and insulin sensitivity, improving metabolic syndrome.
Promotes Muscle Regeneration and Anti-Aging: Studies have shown that 5-Amino-1MQ can activate muscle stem cells and promote the differentiation and fusion of myoblasts. In animal models, it not only enhances grip strength but also synergizes with exercise to combat age-related sarcopenia.
Non-Appetite Suppressant Fat Loss: Unlike drugs such as GLP-1 that reduce weight by suppressing appetite, 5-Amino-1MQ increases basal metabolic rate and energy expenditure at the cellular level, achieving "fat loss without muscle loss" in body restructuring.
Storage Conditions: Solid powder should be sealed and protected from light, frozen and aliquoted at -20°C to avoid repeated freeze-thaw cycles that could destroy activity; diluted solutions should be refrigerated at 2-8°C and used within a short period. Store in a dry environment, away from light, high temperatures, and humidity, and label each reagent separately.
Precautions:
Strictly Prohibited for Human Use: Research-grade compound, no clinical safety data available, and unknown toxicity risks.
Handling Protection: Wear nitrile gloves and goggles. Handle the powder/reconstitute in a fume hood to prevent inhalation of dust or aerosols.
Compatibility: Dissolve the powder in anhydrous DMSO to prepare a stock solution, then dilute. Aqueous solutions are unstable; prepare and use immediately or refrigerate for a short period. Avoid strong light.
Disposal: Dispose of as controlled chemical waste to a qualified unit. Do not pour into sewers.
First Aid: For skin/eye contact, flush with plenty of running water for ≥15 minutes. For inhalation, move to fresh air; seek medical attention if necessary and inform the doctor that it is a highly active small molecule inhibitor.
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