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AOD9604 Peptide Powder Is Used in Metabolic And Lipolysis Research.

AOD9604 Peptide Powder Is Used in Metabolic And Lipolysis Research.

AOD9604 (CAS No. 221231-10-3) is a synthetic hexapeptide whose sequence is derived from the 176-191 amino acid segment at the C-terminus of human growth hormone (HGH), with an additional tyrosine residue added at the N-terminus. Its molecular formula is C₇₈H₁₂₃N₂₃O₂₃S₂, and its molecular weight is approximately 1815.1. This polypeptide maintains its active conformation through disulfide bonds formed between Cys⁷ and Cys¹⁴ within the molecule; this structural feature is crucial to its biological activity.

Product Introduction

Application Scenarios

1. Lipid Metabolism Research

AOD9604 has demonstrated dual activity in studies, promoting lipolysis (fat burning) and inhibiting lipogenesis. Research shows that this peptide specifically targets adipocytes, promoting the release of stored fat while reducing the accumulation of new fat, without affecting feeding behavior or inducing growth hormone-related growth-promoting effects.

2. Weight Management Research

In obese animal models, AOD9604 has shown effects in reducing body weight and the weight of epididymal adipose tissue and brown adipose tissue, making it suitable for studying the mechanisms of obesity and related metabolic disorders.

3. Cartilage and Joint Health Research

Some studies have shown that AOD9604 has potential applications in cartilage regeneration. For example, intra-articular injection of AOD9604 has been observed to promote cartilage repair in a rabbit knee osteoarthritis model.

 

 

Why Choose Us

1. Source Factory, Controllable Costs
We have our own peptide synthesis base, controlling the entire process from amino acid raw material procurement to solid-phase synthesis, cutting and purification, and freeze-drying into powder. With no middlemen involved, we ensure our customers receive the most competitive factory prices, while also supporting bulk customized production (from gram to kilogram).

2. Professional Synthesis Equipment and Mature Process

Synthesis Platform: Equipped with multiple automated solid-phase peptide synthesizers (SPPS), supporting efficient synthesis using Fmoc/tBu strategies.

Purification System: Possesses preparative HPLC (C18 reversed-phase chromatography) and a GMP-grade purification workshop, effectively removing missing peptides, racemates, and byproducts.

Analytical Testing: Equipped with a complete set of quality control equipment including LC-MS, MALDI-TOF, HPLC (purity analysis), amino acid composition analysis, and endotoxin detection.

Choice of Account (COA) is provided for each batch: including HPLC chromatogram, mass spectrometry molecular weight confirmation (target 1815.1±1 Da), peptide content determination, and moisture data.

3. Stable Supply and Guaranteed Delivery Time
Annual production capacity of tens of kilograms of peptide raw materials, with ample inventory of standard specifications.

Established a comprehensive raw material supply chain management system, with strategic stockpiling of key amino acids and reagents.

Support for long-term supply agreements, ensuring uninterrupted supply and stable prices for research institutions and downstream enterprises.

4. Stable Quality and Batch Consistency
Strictly adheres to ISO 9001 standards. Quality management system, traceable from synthesis to packaging.

Purity of each batch ≥98% (HPLC), some batches reach ≥99%. Optimized freeze-drying process, moisture content controlled at ≤5%, ensuring powder stability and reconstitution. Third-party testing and verification mechanism to eliminate batch-to-batch differences.

 

 

Storage and Usage Methods

【Storage Conditions】

Freeze-dried powder (unopened): -20°C ± 5°C for 24–36 months. Sealed and protected from light, avoid repeated freeze-thaw cycles; short-term storage at 2–8°C is acceptable.

Reconstitution solution: Refrigerated at 2–8°C for 24–48 hours. It is recommended to aliquot into smaller portions to avoid repeated freeze-thaw cycles; for long-term storage, aliquot and freeze at -20°C.

⚠️ Important Note: AOD9604 contains disulfide bonds. High temperatures, strong oxidizing environments, or repeated freeze-thaw cycles may cause peptide chain degradation or disulfide bond breakage, affecting activity. Use ice packs/dry ice for insulation during transportation.

[Reconstitution Method]
Solvent Selection: Sterile water for injection or sterile water containing 0.1–1% glacial acetic acid is recommended for initial reconstitution. Subsequent dilution with PBS (pH 7.4) or appropriate buffer solutions can be used as needed for experiments.

Procedure:
Perform the procedure in a clean bench or biosafety cabinet.
Slowly pour the solvent along the bottle wall, avoiding direct impact on the powder.
Gently swirl or rotate at low speed to mix; avoid vigorous vortexing or sonication to prevent the introduction of air bubbles or aggregation.
After the powder is completely dissolved, aliquot or dilute as needed for the experiment.

Concentration Calculation:
Calculate the actual concentration based on the Net Peptide Content stated in the COA.

Formula: Solution volume (mL) = Peptide mass (mg) ÷ Target concentration (mg/mL)

【Usage Recommendations】 This product is a research-grade raw material, for in vitro experiments, cell research, and laboratory analysis only. Wear gloves and protective equipment throughout the process to avoid inhaling dust. Use as soon as possible after opening. Store any unused portion in a sealed container according to the storage conditions described above.

 

 

FAQ
Q: Where is your product manufactured?

A: Our products are from Shenzhen, China.

Q: What is the minimum order quantity?

A: The minimum order quantity is 10 bottles/set.

Q: How long does it take to ship?

A: In-stock orders will be shipped within 24 hours.

Q: What purity level can you provide?

A: Standard purity 99%.

Q: Which courier service do you use?

A: FedEx, DHL, UPS, and postal services are available.

Q: How long does shipping take?

A: Approximately 10-15 days.

Q: Can you provide a COA (Copyright Account) report and HPLC (High-Performance Computing) report?

A: Yes, all goods undergo professional testing before shipment.

Q: Do you support OEM branding?

A: Yes, we support OEM branding, subject to minimum order quantity requirements.

Q: What are your after-sales service details?

A: After receiving the goods, if a quality issue is confirmed to be caused by our manufacturing process, you can enjoy free replacement or a refund. We uphold a pragmatic and responsible service principle, actively responding to and properly handling all kinds of issues, without shirking responsibility or avoiding problems, and fully protecting your rights.

Q: What payment methods are available?

A: We support bank transfer, Bitcoin, Transferwise, and Xoom.

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