Physical Mechanism
Within a membrane environment, the p53 fragment of PNC-27 can adopt a conformation similar to that of the p53–HDM-2 complex, allowing it to bind to HDM-2 present on the surface of cancer cell membranes. Upon binding, its membrane-penetrating domain facilitates amphiphilic interactions, inducing the formation of membrane pores. This triggers selective membrane lysis, ultimately leading to the necrosis of tumor cells. Normal cell membranes typically lack this membrane-localized HDM-2, rendering them significantly less susceptible.
Applications (Research Use Only)
Currently, the use of PNC-27 is strictly limited to preclinical basic research. Published *in vitro* studies have investigated its effects on cell lines derived from pancreatic cancer, cervical cancer, leukemia, melanoma, and breast cancer. In animal models, research has shown that intraperitoneal administration of PNC-27 (40 mg/kg, once daily for 2–3 weeks) exhibits anti-leukemic activity in mouse models of leukemia. Its primary research value lies in serving as a tool to validate the hypothesis of "membrane-HDM-2-targeted membrane lysis," rather than as a therapeutic regimen.
Dietary and Pharmacological Precautions
PNC-27 is a peptide reagent intended solely for scientific research; it must not be self-administered-whether by injection or oral ingestion-or used in humans. Improper use of such peptides may lead to allergic reactions, gastrointestinal distress, strain on liver or kidney function, endocrine fluctuations, or adverse interactions with other medications. Individuals with impaired liver or kidney function, a history of allergies, those who are pregnant or breastfeeding, minors, and individuals currently taking anticoagulants, immunosuppressants, hormones, or anti-diabetic medications should strictly avoid exposure to this substance, which is not approved for human use. The powdered reagent should generally be stored in a dry, dark, and low-temperature environment; repeated freeze-thaw cycles must be avoided.
Why Choose Us
While fully disclosing the aforementioned risks, we offer the following supply chain assurances for research projects that require PNC-27 as an experimental material:
Direct Manufacturer: We possess in-house synthesis capabilities rather than acting as a third-party reseller, ensuring full control over the entire supply chain-from raw materials to the final product. Professional Production Equipment: We utilize industrial-grade Solid-Phase Peptide Synthesis (SPPS) systems and preparative HPLC purification equipment, ensuring consistent quality across different batches.
Reliable Supply: We maintain stock for standard specifications and can schedule production for large-scale orders, ensuring your research remains uninterrupted.
High Purity: Standard delivery purity is ≥97% (via RP-HPLC), with 99% purity options available upon request. Each batch includes HPLC and MS quality control (QC) reports.
Consistent Quality & After-Sales Support: Products are delivered as lyophilized (freeze-dried) powder, with standardized storage and shipping protocols. Should any quality-related issues arise, we provide returns, replacements, and technical support.
FAQ:
Q: Where are your products manufactured?
A: Our products are manufactured in Shenzhen, China.
Q: What is the minimum order quantity (MOQ)?
A: The minimum order quantity is 10 vials/units.
Q: How soon will my order be shipped?
A: Orders for in-stock items are dispatched within 24 hours.
Q: What purity levels do you offer?
A: Our standard purity is 99%.
Q: Which courier services do you use?
A: We offer shipping via FedEx, DHL, UPS, and postal services.
Q: How long does shipping take?
A: Approximately 10–15 days.
Q: Do you provide a Certificate of Analysis (COA) and HPLC test reports?
A: Yes; all products undergo professional testing prior to shipment.
Q: Do you offer OEM/private labeling services?
A: Yes, OEM/private labeling services are available, subject to minimum order quantity (MOQ) requirements.
Q: How do you handle after-sales issues?
A: If a quality issue attributable to our production process is confirmed after you receive the shipment, we offer free replacement or a full refund. We are committed to a pragmatic and responsible service approach-we address all concerns proactively and transparently, ensuring our clients' interests are fully protected.
Q: What payment methods do you accept?
A: We accept bank transfers, Bitcoin, TransferWise, and Xoom.
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