Humanin, a 24-amino acid mitochondrial-derived peptide (MDP) first discovered in the human brain in 2001, is encoded by mitochondrial DNA. Simply put, it's your body's own "cellular survival signal," and its plasma levels decline significantly with age. It's widely used in cell and animal research experiments on neurodegeneration, cellular aging, oxidative damage, and metabolic disorders, and is a crucial raw material for anti-aging and neuroprotective research.
Core Advantages and Functions:
Its most remarkable feature is that it's one of the very few short peptides that can directly combat Alzheimer's disease (AD)-related toxicity at the genetic level. When amyloid-beta (Aβ) accumulates in the brain, Humanin acts like a shield, specifically antagonizing this neurotoxicity and pulling neurons back from the brink of apoptosis. Moreover, it not only protects the brain but also binds to pro-apoptotic proteins (such as Bax), stabilizing mitochondria and combating oxidative stress. The longevity medicine community is now paying particular attention to it because studies have found that humanin levels are generally high in centenarians; it's practically the body's own "anti-aging and cellular survival switch."
Storage Conditions
Humanin lyophilized powder has **moderate stability and is somewhat delicate**, and is most susceptible to temperature fluctuations and oxidation!
For long-term storage, it must be **alimited into small portions** and frozen at -20°C away from light**. Repeated freeze-thaw cycles are strictly prohibited, as they will directly damage the peptide structure and cause loss of anti-apoptotic activity.
It can be stored at room temperature for a few weeks in the short term, but this is not recommended.
The dissolved working solution should be refrigerated at 2–8°C and used within 7 days. For long-term storage, it is recommended to add a small amount of BSA for protection and then aliquot and freeze at -20°C.
Store in a dark, dry place, away from high temperatures, heat sources, and humid environments. Label separately and do not mix with strong oxidants, strong acids, or strong alkalis.
Precautions & Contraindications
Research Use: There is currently no human clinical safety data. It must not be used as a drug for self-injection or oral administration (oral administration will result in complete degradation by digestive enzymes).
Theoretical Cancer Risk: Because it inhibits apoptosis, it may theoretically allow abnormally proliferating cells to escape elimination-avoid use by patients with active malignant tumors and those undergoing chemotherapy.
Effects on blood sugar: May enhance insulin sensitivity; caution should be exercised regarding hypoglycemia in patients using insulin or sulfonylureas.
Contraindications: No safety data available for pregnant/breastfeeding women/those under 18 years of age; contraindicated in individuals with peptide allergies; caution is advised for those with severe autoimmune diseases.
Injection reactions: May include redness and swelling at the injection site, mild fatigue, or transient headache, which usually resolves spontaneously.
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