Chinese Common Name: CJC-1295 with DAC / Drug Affinity Complex Modified CJC-1295
English Full Name: CJC-1295 with Drug Affinity Complex (DAC)
CAS Number: 446262-90-4
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.9 Da
Structural Type: Synthetic analog of growth hormone-releasing hormone (GHRH), terminally conjugated with a drug affinity complex (DAC)
Appearance: White to off-white lyophilized powder
Storage Conditions: Store at -20°C, protected from light, in a dry environment, and under inert gas protection.
Extremely Long Half-Life (Core Feature): Through conjugation with a drug affinity complex (DAC), it can non-covalently bind to endogenous albumin, thereby avoiding rapid renal clearance and plasma protease degradation. Its half-life in vivo is significantly prolonged, with an action time of up to approximately 14 days.
Sustained secretion-stimulating effect: As a GHRH analog, it continuously stimulates the anterior pituitary gland to release growth hormone (GH). A single injection can increase plasma GH levels by 2 to 10 times and maintain this effect for more than 6 days; simultaneously, it increases insulin-like growth factor 1 (IGF-1) levels by 0.5 to 3 times, maintaining this effect for 9 to 11 days.
Pulsating physiological release: Unlike direct injection of recombinant growth hormone, CJC-1295 with DAC mimics the body's natural growth hormone secretion rhythm, maintaining a sustained increase in IGF-1 levels within the physiological range and avoiding receptor desensitization.
Tissue synthesis and metabolic regulation: In research models, it has demonstrated effects in promoting muscle protein synthesis, accelerating lipid oxidation metabolism, improving bone density, and promoting ligament/joint tissue repair.
Endocrine and metabolic research: As a long-acting GHRH agonist, it is widely used to study the regulatory mechanisms of growth hormone secretion, interventions in aging models, and pathophysiological experiments of metabolic syndrome.
**Sports Medicine and Tissue Repair:** Used to evaluate the pharmacodynamics of long-acting growth hormone peptides in animal models of muscle hypertrophy, tendon/ligament injury repair, and increased bone mineral density.
**Pharmacokinetic (PK) Studies:** Due to its unique albumin-binding properties, it is often used as a standard tool compound for studying peptide-albumin interactions, long-circulating peptide drug design, and in vivo metabolic pathways.
**Anti-aging Mechanism Exploration:** Used in cell and animal models to investigate the molecular mechanisms by which exogenous and sustained enhancement of the GH/IGF-1 axis improves skin quality, promotes cell regeneration, and restores overall vitality.
For the complex structure of CJC-1295 with DAC and various research needs, we offer the following in-depth customization services:
**Purity and Scale Customization:** Supporting large-scale synthesis from milligrams (research exploration) to hundreds of grams per kilogram (pilot-scale amplification), providing different HPLC purity specifications such as ≥95%, ≥98%, and ≥99%.
****** Structural Modification and Labeling: Offers N-terminal/C-terminal modification, PEGylation (to further extend half-life), and fluorescent or affinity labeling such as FITC/CY5/Biotin to meet the needs of cell tracing or receptor binding experiments.
Customized Salt Forms: In addition to standard acetate peptides, supports conversion to different salt forms such as trifluoroacetate (TFA) and hydrochloride to adapt to specific solubility or formulation requirements.
Comprehensive Quality Control Analysis: Provides a complete Certificate of Account (COA) report for each batch, covering key indicators such as HPLC purity, MS molecular weight confirmation, amino acid composition analysis, moisture (Karl Fischer), peptide content, and endotoxin detection.
FAQ
Q: What are the current standard specifications? How long does it take to ship after placing an order?
A: 2mg, 5mg, and 10mg are the mainstream specifications and are usually in stock. Orders placed before 4 PM on weekdays can generally be shipped out the same day. For large orders or bulk packages of raw materials, please communicate in advance to schedule the shipment and confirm the exact delivery time.
Q: Can large packages of raw materials be split into smaller vials?
A: Yes, whether it's bulk raw materials being split into standard vials or customizing non-standard single-vial weights, we can handle it as needed.
Q: Does every batch come with a test report? Do you support third-party retesting?
A: Each batch comes with a paper and electronic COA test report, and the data is verifiable. Customers can send products to third-party institutions for retesting; all purity levels are based on actual test results.
Q: Will there be data discrepancies when comparing different batches of products?
A: The entire production process is standardized, with consistent raw materials and purification processes. The differences between batches are minimal, fully meeting the requirements for long-term repeated experiments and multi-batch comparative experiments.
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